Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 5259298..5259944 Replicon chromosome
Accession NZ_CP090078
Organism Klebsiella michiganensis strain KM41

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8T6QFJ5
Locus tag LW125_RS25215 Protein ID WP_024360470.1
Coordinates 5259298..5259639 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag LW125_RS25220 Protein ID WP_233934680.1
Coordinates 5259660..5259944 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LW125_RS25200 5255488..5255949 + 462 WP_109213744.1 hypothetical protein -
LW125_RS25205 5255960..5257093 + 1134 WP_233934644.1 PAAR domain-containing protein -
LW125_RS25210 5258027..5259034 - 1008 WP_220152592.1 restriction endonuclease -
LW125_RS25215 5259298..5259639 - 342 WP_024360470.1 TA system toxin CbtA family protein Toxin
LW125_RS25220 5259660..5259944 - 285 WP_233934680.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LW125_RS25225 5260012..5260554 - 543 WP_220152594.1 DNA repair protein RadC -
LW125_RS25230 5260566..5261009 - 444 WP_136455085.1 antirestriction protein -
LW125_RS25235 5261040..5261861 - 822 WP_220152595.1 DUF932 domain-containing protein -
LW125_RS25240 5261981..5262454 - 474 WP_048999847.1 hypothetical protein -
LW125_RS25245 5262526..5262978 - 453 WP_192468078.1 hypothetical protein -
LW125_RS25250 5263026..5263730 - 705 WP_220152596.1 WYL domain-containing protein -
LW125_RS25255 5263974..5264849 - 876 WP_220152597.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - clpV/tssH / hcp/tssD / vipB/tssC / vipA/tssB 5232970..5269967 36997


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(1-92)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12793.70 Da        Isoelectric Point: 8.4941

>T230020 WP_024360470.1 NZ_CP090078:c5259639-5259298 [Klebsiella michiganensis]
MKTLPATNPQAATLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T230020 NZ_CP124662:c4958155-4957400 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10636.04 Da        Isoelectric Point: 6.6243

>AT230020 WP_233934680.1 NZ_CP090078:c5259944-5259660 [Klebsiella michiganensis]
MTPCFGARLVQEGNRLHYLADRACVTGEFSNAESLKLDEVFTRFIRQMESMLTTGEMNPRHAHSVTLYHNGFTCEADTLG
SCGYVYIAVYPTHR

Download         Length: 285 bp

>AT230020 NZ_CP124662:c4958658-4958290 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References