Detailed information of TA system TA230019

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4740192..4741011
• Replicon: chromosome
• Accession: NZ_CP090078
• Organism: Klebsiella michiganensis strain KM41

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: LW125_RS22810
• Protein ID: WP_004110819.1
• Coordinates: 4740754..4741011 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: LW125_RS22805
• Protein ID: WP_220151876.1
• Coordinates: 4740192..4740743 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LW125_RS22785	4735583..4736980	+	1398	WP_009654185.1	MFS transporter	-
LW125_RS22790	4737103..4738443	+	1341	WP_086530462.1	carbohydrate porin	-
LW125_RS22795	4738546..4739292	-	747	WP_224250388.1	class I SAM-dependent methyltransferase	-
LW125_RS22800	4739716..4740078	-	363	Protein_4488	class I SAM-dependent methyltransferase	-
LW125_RS22805	4740192..4740743	-	552	WP_220151876.1	N-acetyltransferase	Antitoxin
LW125_RS22810	4740754..4741011	-	258	WP_004110819.1	YjhX family toxin	Toxin
LW125_RS22815	4741687..4742871	+	1185	WP_048261308.1	mannonate dehydratase	-
LW125_RS22820	4742945..4744420	+	1476	WP_004847988.1	fructuronate reductase	-
LW125_RS22825	4744559..4745335	+	777	WP_004847986.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T230019 WP_004110819.1 NZ_CP090078:c4741011-4740754 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T230019 NZ_CP124662:3971914-3972492 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAGCGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20122.00 Da
• Isoelectric Point: 6.6519

>AT230019 WP_220151876.1 NZ_CP090078:c4740743-4740192 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKREPDSPMMH
ILAPLAVVPEYQGVGVGGGLIRHGIEQLKAMGSQMVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT230019 NZ_CP124662:3971272-3971826 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2