Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1362886..1363520 Replicon chromosome
Accession NZ_CP090078
Organism Klebsiella michiganensis strain KM41

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LW125_RS06595 Protein ID WP_006687278.1
Coordinates 1363116..1363520 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LW125_RS06590 Protein ID WP_220151913.1
Coordinates 1362886..1363116 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LW125_RS06580 1359054..1360583 + 1530 WP_220151915.1 AAA family ATPase -
LW125_RS06585 1361031..1361906 - 876 WP_220151914.1 integrase domain-containing protein -
LW125_RS06590 1362886..1363116 + 231 WP_220151913.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LW125_RS06595 1363116..1363520 + 405 WP_006687278.1 tRNA(fMet)-specific endonuclease VapC Toxin
LW125_RS06600 1363543..1364766 - 1224 WP_220151912.1 radical SAM protein -
LW125_RS06605 1365156..1366397 + 1242 WP_220151965.1 MFS transporter -
LW125_RS06610 1366457..1367470 - 1014 WP_220151964.1 Gfo/Idh/MocA family oxidoreductase -
LW125_RS06615 1367481..1368461 - 981 WP_220151911.1 PTS glucitol/sorbitol transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1348437..1379616 31179


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14977.31 Da        Isoelectric Point: 7.8441

>T230008 WP_006687278.1 NZ_CP090078:1363116-1363520 [Klebsiella michiganensis]
MLKYMLDTNICIYTIKNKPQAVREAFNQHYGRMCISSVTLMELIYGAEKSASPEKNLRVVEGFIARLEVLNYGIDAAVQT
GQIRAELARAGTPVGPYDSMIAAHARALGLILVTNNTREFERINGLRLEDWSIS

Download         Length: 405 bp

>T230008 NZ_CP124659:244460-244984 [Pseudomonas aeruginosa]
ATGAAAATCATCGGAGTGCAGGACCTCCCCTGCTACCGAATGCACACTCCCAAGTGGTCCGTTGCGCCTACATCTGGAGC
TGGAGCTGCAACTCAGGGTGGCCGGGTTAACCGAAAGGGGCTAGAGGCTCTATACCTCTCGCTGGAGTCGGCAACGGCCA
TTGCTGAGTTTCAGCAAGCAAGCGCATTCCTTCCACCAGGTCTGCTGGTCAGCTATTCCCTCAGTCTGGATCGAGTTATC
GACTTCACCGGCGGCTATGACGATACCTGGGCCCCGATCTGGCAAGACTTCTTCTGCGACTGGAGAAAGATTCGCTTCAA
CGACGGCGTTGAACCGCCGAGCTGGATTATCGGGGATCTGGCTATCGAGGCTGACTGTGCTGGGATTCTGTTCGAGTCCG
TTGCGAACCCTGGAGGTCGGAACCTGGTGCTTTTCACCGATCAGTTGCCGGTGCATGGGAATATTGTGGTCAACGATCCT
CGCGGGGATCTCCCTACCGACCAGTCATCTTGGATGCGCCCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8479.46 Da        Isoelectric Point: 4.7672

>AT230008 WP_220151913.1 NZ_CP090078:1362886-1363116 [Klebsiella michiganensis]
MEKTTVFKSNRSQAVRLPKAVALPEDVKHVDIVAVGRTRIITPAGESWDSWFDGESVTSDFMAAREQPGEQDREGF

Download         Length: 231 bp

>AT230008 NZ_CP124659:244068-244463 [Pseudomonas aeruginosa]
ATGGCCAGCAAAGCCGTATTAGAGCTTCGCCCCACCAACTTCGCGGGCTTGATGGACGCTCTCAAAGAGGTGAACCGTGT
GATGTTCTCCCCTGAGCGCTTCCTCAAGGTTTTTTCGATGGACCAGCAGACCTTGGCGCTCCGGGCCCATGTCCATCGCA
ACACTGTGCGCAACGCGCCTGAATCGGAAAAGGTCCAGGCCTACATTCGTGATTCAGTGAAGGTTCTGCGTGCAGTGACC
GACATGGGCACGGACGTGACGAATGCCATCTTCTGGTTTAAGAACGAGCCTCTTTCCACGTTCAACTATAAGACCGCGGA
GGAAGTGGTCAGCGAAGGAAAAACCGAGCAGCTGATCGCTTTCCTTCAATCCTGGGAAGCTGGTGCCCAAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References