Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 745675..746428 | Replicon | chromosome |
| Accession | NZ_CP090078 | ||
| Organism | Klebsiella michiganensis strain KM41 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | R8WN26 |
| Locus tag | LW125_RS03610 | Protein ID | WP_016154457.1 |
| Coordinates | 745675..746052 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | LW125_RS03615 | Protein ID | WP_162838704.1 |
| Coordinates | 746102..746428 (-) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LW125_RS03585 | 741753..741995 | + | 243 | WP_004854184.1 | hypothetical protein | - |
| LW125_RS03590 | 742265..743653 | + | 1389 | WP_004854182.1 | DASS family sodium-coupled anion symporter | - |
| LW125_RS03595 | 744028..744873 | - | 846 | Protein_704 | DUF4942 domain-containing protein | - |
| LW125_RS03600 | 744954..745157 | - | 204 | WP_009652505.1 | DUF957 domain-containing protein | - |
| LW125_RS03605 | 745187..745678 | - | 492 | WP_009652438.1 | DUF5983 family protein | - |
| LW125_RS03610 | 745675..746052 | - | 378 | WP_016154457.1 | TA system toxin CbtA family protein | Toxin |
| LW125_RS03615 | 746102..746428 | - | 327 | WP_162838704.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LW125_RS03620 | 746485..746706 | - | 222 | WP_009652392.1 | DUF987 domain-containing protein | - |
| LW125_RS03625 | 746720..747202 | - | 483 | WP_016154455.1 | DNA repair protein RadC | - |
| LW125_RS03630 | 747214..747432 | - | 219 | WP_009652503.1 | hypothetical protein | - |
| LW125_RS03635 | 747443..747916 | - | 474 | WP_009652453.1 | antirestriction protein | - |
| LW125_RS03640 | 747933..748187 | - | 255 | WP_009652519.1 | hypothetical protein | - |
| LW125_RS03645 | 748187..749005 | - | 819 | WP_009652424.1 | DUF932 domain-containing protein | - |
| LW125_RS03650 | 749109..749342 | - | 234 | WP_009652474.1 | DUF905 domain-containing protein | - |
| LW125_RS03655 | 749398..749619 | - | 222 | WP_009652443.1 | hypothetical protein | - |
| LW125_RS03660 | 749702..750214 | - | 513 | WP_009652395.1 | DUF4234 domain-containing protein | - |
| LW125_RS03665 | 750263..750733 | - | 471 | WP_009652431.1 | hypothetical protein | - |
| LW125_RS03670 | 750780..751091 | - | 312 | WP_009652410.1 | hypothetical protein | - |
| LW125_RS03675 | 751104..751370 | - | 267 | WP_009652486.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 734424..824963 | 90539 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14168.19 Da Isoelectric Point: 9.5224
>T230006 WP_016154457.1 NZ_CP090078:c746052-745675 [Klebsiella michiganensis]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP
Download Length: 378 bp
>T230006 NZ_CP124658:c5846566-5846288 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGCTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGCTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12079.85 Da Isoelectric Point: 6.6283
>AT230006 WP_162838704.1 NZ_CP090078:c746428-746102 [Klebsiella michiganensis]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE
Download Length: 327 bp
>AT230006 NZ_CP124658:c5846276-5845971 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAATGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAATGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|