Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3250411..3250995 Replicon chromosome
Accession NZ_CP090067
Organism Acinetobacter sp. SH20PTE14

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LXF01_RS15830 Protein ID WP_233944700.1
Coordinates 3250693..3250995 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LXF01_RS15825 Protein ID WP_233944699.1
Coordinates 3250411..3250692 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXF01_RS15800 (LXF01_15800) 3245433..3246530 - 1098 WP_233944696.1 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase -
LXF01_RS15805 (LXF01_15805) 3246833..3247777 - 945 WP_180131198.1 glutathione synthase -
LXF01_RS15810 (LXF01_15810) 3248100..3249002 + 903 WP_233944697.1 GGDEF domain-containing protein -
LXF01_RS15815 (LXF01_15815) 3249129..3249326 + 198 WP_180101671.1 DUF3565 domain-containing protein -
LXF01_RS17550 3249338..3249460 - 123 WP_267967471.1 hypothetical protein -
LXF01_RS15820 (LXF01_15820) 3249639..3250331 + 693 WP_233944698.1 hypothetical protein -
LXF01_RS15825 (LXF01_15825) 3250411..3250692 - 282 WP_233944699.1 putative addiction module antidote protein Antitoxin
LXF01_RS15830 (LXF01_15830) 3250693..3250995 - 303 WP_233944700.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXF01_RS15835 (LXF01_15835) 3251150..3251758 - 609 WP_078194113.1 NAD(P)H-dependent oxidoreductase -
LXF01_RS15840 (LXF01_15840) 3251857..3252768 + 912 WP_180161303.1 LysR family transcriptional regulator -
LXF01_RS15845 (LXF01_15845) 3253099..3253749 - 651 WP_078193224.1 orotate phosphoribosyltransferase -
LXF01_RS15850 (LXF01_15850) 3253790..3254608 + 819 WP_078193225.1 exodeoxyribonuclease III -
LXF01_RS15855 (LXF01_15855) 3255238..3255585 + 348 WP_078193226.1 Spx/MgsR family RNA polymerase-binding regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11573.12 Da        Isoelectric Point: 4.8894

>T230003 WP_233944700.1 NZ_CP090067:c3250995-3250693 [Acinetobacter sp. SH20PTE14]
MYSIYTTEVFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGKRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp

>T230003 NZ_CP124658:c4763395-4762640 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCGTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10151.75 Da        Isoelectric Point: 8.0018

>AT230003 WP_233944699.1 NZ_CP090067:c3250692-3250411 [Acinetobacter sp. SH20PTE14]
MAIKLRKWDSAEHLKTEEDMQAYLQACIEESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLVI

Download         Length: 282 bp

>AT230003 NZ_CP124658:c4763898-4763530 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References