Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 736885..737534 Replicon chromosome
Accession NZ_CP090067
Organism Acinetobacter sp. SH20PTE14

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LXF01_RS03610 Protein ID WP_078192327.1
Coordinates 737115..737534 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LXF01_RS03605 Protein ID WP_078191134.1
Coordinates 736885..737115 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXF01_RS03595 (LXF01_03595) 733219..735837 + 2619 WP_180173143.1 Fe/S-dependent 2-methylisocitrate dehydratase AcnD -
LXF01_RS17505 735920..736225 + 306 WP_257233996.1 hypothetical protein -
LXF01_RS03600 (LXF01_03600) 736155..736817 + 663 WP_257233995.1 hypothetical protein -
LXF01_RS03605 (LXF01_03605) 736885..737115 + 231 WP_078191134.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LXF01_RS03610 (LXF01_03610) 737115..737534 + 420 WP_078192327.1 type II toxin-antitoxin system VapC family toxin Toxin
LXF01_RS03615 (LXF01_03615) 737595..737810 + 216 WP_111884814.1 hypothetical protein -
LXF01_RS03620 (LXF01_03620) 737938..738513 + 576 WP_111884815.1 DUF4126 domain-containing protein -
LXF01_RS03625 (LXF01_03625) 738662..739153 + 492 WP_078192325.1 DUF2569 domain-containing protein -
LXF01_RS03630 (LXF01_03630) 739370..739579 + 210 WP_180107296.1 hypothetical protein -
LXF01_RS03635 (LXF01_03635) 739685..739942 + 258 WP_180021364.1 hypothetical protein -
LXF01_RS03640 (LXF01_03640) 741366..741824 + 459 WP_180173142.1 GIY-YIG nuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16163.53 Da        Isoelectric Point: 6.2194

>T230002 WP_078192327.1 NZ_CP090067:737115-737534 [Acinetobacter sp. SH20PTE14]
MPTQYLLDTNICIYITKHQPEIVRQHFEKHLPDGNIFISVITLGELRFGAEKSQWKDKAFKVIDELTSIIPVIELDEHTA
VHYAQIRKQLALQGQIIGNNDLWLAAHARSNNWVMVTNNEKEFLRVDELQVENWLSKSL

Download         Length: 420 bp

>T230002 NZ_CP124658:3742691-3743269 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCACTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGATAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8995.26 Da        Isoelectric Point: 4.6936

>AT230002 WP_078191134.1 NZ_CP090067:736885-737115 [Acinetobacter sp. SH20PTE14]
MTTAKVFMTGRSQAIRLPKEFRFEGKEVEIFRRGDEVILREKPVTADQLFKVLAQMPDDFYAETRVDEPPQEREEF

Download         Length: 231 bp

>AT230002 NZ_CP124658:3742048-3742602 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCCCGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References