Detailed information of TA system TA229991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 885354..885879
• Replicon: chromosome
• Accession: NZ_CP090065
• Organism: Pectobacterium polonicum strain BY21311

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LW347_RS03940
• Protein ID: WP_258884232.1
• Coordinates: 885354..885638 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C6D956
• Locus tag: LW347_RS03945
• Protein ID: WP_005973616.1
• Coordinates: 885628..885879 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LW347_RS03905 (LW347_03900)	880877..881503	-	627	WP_137742320.1	LysE family transporter	-
LW347_RS03910 (LW347_03905)	881706..882164	-	459	WP_137742319.1	hypothetical protein	-
LW347_RS03915 (LW347_03910)	882269..882598	+	330	WP_137742318.1	DUF1493 family protein	-
LW347_RS03920 (LW347_03915)	883023..883538	-	516	WP_039355527.1	GNAT family N-acetyltransferase	-
LW347_RS03925 (LW347_03920)	883540..883806	-	267	WP_039355529.1	DUF1778 domain-containing protein	-
LW347_RS03930 (LW347_03925)	884110..884601	+	492	WP_137742315.1	DUF2559 family protein	-
LW347_RS03935 (LW347_03930)	884594..885178	+	585	WP_258884231.1	putative adenosine monophosphate-protein transferase Fic	-
LW347_RS03940 (LW347_03935)	885354..885638	-	285	WP_258884232.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LW347_RS03945 (LW347_03940)	885628..885879	-	252	WP_005973616.1	prevent-host-death protein	Antitoxin
LW347_RS03950 (LW347_03945)	886140..886898	-	759	Protein_758	primase-like DNA-binding domain-containing protein	-
LW347_RS03955 (LW347_03950)	887016..887495	+	480	WP_258884233.1	hypothetical protein	-
LW347_RS03960 (LW347_03955)	887535..887783	+	249	WP_258884234.1	ogr/Delta-like zinc finger family protein	-
LW347_RS03965 (LW347_03960)	888398..889747	+	1350	WP_224554747.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10980.93 Da
• Isoelectric Point: 10.0255

>T229991 WP_258884232.1 NZ_CP090065:c885638-885354 [Pectobacterium polonicum]
MSYKLEFEEHALKEFKKLGAPVREQFTKKLKEVLQNPHVPANRLHGMADCYKIKLRSVGYRLVYQVLEHEIVVLVLAVGK
RERSEVYKAAKDQL

Nucleotide

• Length: 285 bp

>T229991 NZ_CP124655:6834616-6834897 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9079.35 Da
• Isoelectric Point: 5.0807

>AT229991 WP_005973616.1 NZ_CP090065:c885879-885628 [Pectobacterium polonicum]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Nucleotide

• Length: 252 bp

>AT229991 NZ_CP124655:6834392-6834619 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0G4JQP6