Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 191503..192120 Replicon chromosome
Accession NZ_CP090065
Organism Pectobacterium polonicum strain BY21311

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LW347_RS00885 Protein ID WP_137741518.1
Coordinates 191941..192120 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LW347_RS00880 Protein ID WP_103862293.1
Coordinates 191503..191913 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LW347_RS00865 (LW347_00865) 187406..188449 - 1044 WP_137741521.1 DNA-binding transcriptional regulator CytR -
LW347_RS00870 (LW347_00870) 188720..190918 - 2199 WP_258883735.1 primosomal protein N' -
LW347_RS00875 (LW347_00875) 191191..191406 + 216 WP_010281510.1 50S ribosomal protein L31 -
LW347_RS00880 (LW347_00880) 191503..191913 - 411 WP_103862293.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LW347_RS00885 (LW347_00885) 191941..192120 - 180 WP_137741518.1 type II toxin-antitoxin system HicA family toxin Toxin
LW347_RS00890 (LW347_00890) 192220..193230 - 1011 WP_039508126.1 iron ABC transporter permease -
LW347_RS00895 (LW347_00895) 193227..194189 - 963 WP_258883736.1 ABC transporter substrate-binding protein -
LW347_RS00900 (LW347_00900) 194199..194996 - 798 WP_258883737.1 ABC transporter ATP-binding protein -
LW347_RS00905 (LW347_00905) 195213..195530 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
LW347_RS00910 (LW347_00910) 195717..196877 + 1161 WP_258883738.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6619.80 Da        Isoelectric Point: 11.0566

>T229986 WP_137741518.1 NZ_CP090065:c192120-191941 [Pectobacterium polonicum]
MDSRTLIAEIKADGWELIRVNRSHHHFMPPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T229986 NZ_CP124655:2192634-2193389 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14461.35 Da        Isoelectric Point: 4.4227

>AT229986 WP_103862293.1 NZ_CP090065:c191913-191503 [Pectobacterium polonicum]
MFYPIAIEAGDETHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIGLLVEMGQDIPTVSSVGQLAKNAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp

>AT229986 NZ_CP124655:2192131-2192499 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References