Detailed information of TA system TA229984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 803289..803901
• Replicon: chromosome
• Accession: NZ_CP090064
• Organism: Proteus vulgaris strain Ld01

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A379EIK6
• Locus tag: LW139_RS03795
• Protein ID: WP_006535062.1
• Coordinates: 803289..803492 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: LW139_RS03800
• Protein ID: WP_109407971.1
• Coordinates: 803539..803901 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LW139_RS03775 (LW139_03775)	799950..800288	+	339	WP_227336448.1	P-II family nitrogen regulator	-
LW139_RS03780 (LW139_03780)	800301..801593	+	1293	WP_227336449.1	ammonium transporter AmtB	-
LW139_RS03785 (LW139_03785)	801637..802512	-	876	WP_166539498.1	acyl-CoA thioesterase II	-
LW139_RS03795 (LW139_03795)	803289..803492	-	204	WP_006535062.1	HHA domain-containing protein	Toxin
LW139_RS03800 (LW139_03800)	803539..803901	-	363	WP_109407971.1	Hha toxicity modulator TomB	Antitoxin
LW139_RS03805 (LW139_03805)	804533..807682	-	3150	WP_166539499.1	efflux RND transporter permease subunit	-
LW139_RS03810 (LW139_03810)	807697..808890	-	1194	WP_109407969.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-113)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8061.34 Da
• Isoelectric Point: 6.9770

>T229984 WP_006535062.1 NZ_CP090064:c803492-803289 [Proteus vulgaris]
MTKTDYLMRLRKCTSIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Nucleotide

• Length: 204 bp

>T229984 NZ_CP124655:1423051-1423350 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 14004.89 Da
• Isoelectric Point: 4.6034

>AT229984 WP_109407971.1 NZ_CP090064:c803901-803539 [Proteus vulgaris]
MDEYSPEKVDLAELSFLCEELLQQALGSLDKGNTVWHNDLSSTKSVDLNVLIEHIMDFSWKFKIKYPDKQVINTLIEEYL
EETYRLFGNTSISYSDINNWKELNHSLLTLIAKNPKSYIK

Nucleotide

• Length: 363 bp

>AT229984 NZ_CP124655:1423347-1423637 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGATAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Structures

Toxin

• AlphaFold DB: A0A379EIK6