Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 756567..757206 Replicon chromosome
Accession NZ_CP090064
Organism Proteus vulgaris strain Ld01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LW139_RS03580 Protein ID WP_166539476.1
Coordinates 756567..756971 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LW139_RS03585 Protein ID WP_088493701.1
Coordinates 756964..757206 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LW139_RS03550 (LW139_03550) 751808..752257 + 450 WP_006535128.1 transcriptional regulator NrdR -
LW139_RS03555 (LW139_03555) 752328..753482 + 1155 WP_166539474.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
LW139_RS03560 (LW139_03560) 753695..754165 + 471 WP_036932916.1 6,7-dimethyl-8-ribityllumazine synthase -
LW139_RS03565 (LW139_03565) 754194..754610 + 417 WP_109408009.1 transcription antitermination factor NusB -
LW139_RS03570 (LW139_03570) 754714..755697 + 984 WP_109408008.1 thiamine-phosphate kinase -
LW139_RS03575 (LW139_03575) 755792..756127 - 336 WP_166539475.1 zinc ribbon domain-containing protein YjdM -
LW139_RS03580 (LW139_03580) 756567..756971 - 405 WP_166539476.1 type II toxin-antitoxin system VapC family toxin Toxin
LW139_RS03585 (LW139_03585) 756964..757206 - 243 WP_088493701.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LW139_RS03590 (LW139_03590) 757325..758323 - 999 WP_282186897.1 ribose operon transcriptional repressor RbsR -
LW139_RS03595 (LW139_03595) 758337..759263 - 927 WP_247850630.1 ribokinase -
LW139_RS03600 (LW139_03600) 759339..760229 - 891 WP_166539478.1 ribose ABC transporter substrate-binding protein RbsB -
LW139_RS03605 (LW139_03605) 760272..761237 - 966 WP_166539479.1 ribose ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15313.52 Da        Isoelectric Point: 7.4647

>T229983 WP_166539476.1 NZ_CP090064:c756971-756567 [Proteus vulgaris]
MIKYLLDTNIVIFTIKRRPEFLLPKFNQYVEQLAISTITLAELLYGAEKSSNSAKNLATVNDFVSRLNVLPYDELAAFHY
GDIRATLEKQGKRIGDNDLHIAAHARSKGLIVVTNNTKEFERVDGLRIEDWTHH

Download         Length: 405 bp

>T229983 NZ_CP124655:1212113-1212391 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9316.41 Da        Isoelectric Point: 4.7969

>AT229983 WP_088493701.1 NZ_CP090064:c757206-756964 [Proteus vulgaris]
MIQHGKVFMSNRTQNVRLPADTRFPDDVKDVVVRVKGKERIITPIQNAWDSFFLSEKSVTDDFLSERPDQVTSERESFDD

Download         Length: 243 bp

>AT229983 NZ_CP124655:1212403-1212708 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAATGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References