Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2774186..2774702 Replicon chromosome
Accession NZ_CP090061
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP-NE368

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LRM38_RS13940 Protein ID WP_002886902.1
Coordinates 2774186..2774470 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LRM38_RS13945 Protein ID WP_002886901.1
Coordinates 2774460..2774702 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM38_RS13915 (LRM38_13900) 2769670..2769933 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LRM38_RS13920 (LRM38_13905) 2770063..2770236 + 174 WP_002886906.1 hypothetical protein -
LRM38_RS13925 (LRM38_13910) 2770239..2770982 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LRM38_RS13930 (LRM38_13915) 2771339..2773477 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LRM38_RS13935 (LRM38_13920) 2773718..2774182 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRM38_RS13940 (LRM38_13925) 2774186..2774470 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRM38_RS13945 (LRM38_13930) 2774460..2774702 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRM38_RS13950 (LRM38_13935) 2774780..2776690 - 1911 WP_004152270.1 PRD domain-containing protein -
LRM38_RS13955 (LRM38_13940) 2776713..2777867 - 1155 WP_002886900.1 lactonase family protein -
LRM38_RS13960 (LRM38_13945) 2777933..2778673 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T229966 WP_002886902.1 NZ_CP090061:c2774470-2774186 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T229966 NZ_CP124651:c5804187-5803897 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
CTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCTCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCGACATTGAAAACCATGCTGGCA
GTAATGCGAGCTTTGGGCGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT229966 WP_002886901.1 NZ_CP090061:c2774702-2774460 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT229966 NZ_CP124651:c5804483-5804184 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References