Detailed information of TA system TA229946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 4303911..4304455
• Replicon: chromosome
• Accession: NZ_CP090059
• Organism: Sphingomonas cannabina strain DM2-R-LB4

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LZK98_RS20100
• Protein ID: WP_233784280.1
• Coordinates: 4303911..4304108 (-)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LZK98_RS20105
• Protein ID: WP_233784281.1
• Coordinates: 4304183..4304455 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZK98_RS20090 (LZK98_20090)	4300561..4301841	+	1281	WP_233784278.1	glycoside hydrolase family 130 protein	-
LZK98_RS20095 (LZK98_20095)	4301816..4303765	-	1950	WP_233784279.1	oligopeptide transporter, OPT family	-
LZK98_RS20100 (LZK98_20100)	4303911..4304108	-	198	WP_233784280.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZK98_RS20105 (LZK98_20105)	4304183..4304455	-	273	WP_233784281.1	CopG family ribbon-helix-helix protein	Antitoxin
LZK98_RS20110 (LZK98_20110)	4304528..4305736	-	1209	WP_233784282.1	M20 family metallopeptidase	-
LZK98_RS20115 (LZK98_20115)	4306080..4308365	+	2286	WP_233784283.1	TonB-dependent receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-63)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7324.35 Da
• Isoelectric Point: 6.8775

>T229946 WP_233784280.1 NZ_CP090059:c4304108-4303911 [Sphingomonas cannabina]
MRAAKVIGEHLKTLERFPTVGRPVHDGLRELVIGFGESGYVALYHYDPAEDAVLLAFRHQREAGY

Nucleotide

• Length: 198 bp

>T229946 NZ_CP124648:c1496944-1496666 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGGCTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCAGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10310.46 Da
• Isoelectric Point: 4.9249

>AT229946 WP_233784281.1 NZ_CP090059:c4304455-4304183 [Sphingomonas cannabina]
MATSVKLDEELKGRVQKLAAARDRSPHWVMREAIRQYVDREEARDGFEREALASWIAYRETGRHLTGDEVAAWLETWGTP
AETAVPDCHD

Nucleotide

• Length: 273 bp

>AT229946 NZ_CP124648:c1496654-1496349 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG