Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3278337..3279004 Replicon chromosome
Accession NZ_CP090059
Organism Sphingomonas cannabina strain DM2-R-LB4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LZK98_RS15490 Protein ID WP_233783390.1
Coordinates 3278612..3279004 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LZK98_RS15485 Protein ID WP_233783388.1
Coordinates 3278337..3278615 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZK98_RS15460 (LZK98_15460) 3273524..3275077 - 1554 WP_233783379.1 hypothetical protein -
LZK98_RS15465 (LZK98_15465) 3275212..3276519 + 1308 WP_233783381.1 UDP-glucose/GDP-mannose dehydrogenase family protein -
LZK98_RS15470 (LZK98_15470) 3276529..3276834 + 306 WP_233783383.1 alkylphosphonate utilization protein -
LZK98_RS15475 (LZK98_15475) 3276872..3277117 - 246 WP_233783384.1 hypothetical protein -
LZK98_RS15480 (LZK98_15480) 3277234..3278226 - 993 WP_233783386.1 cysteine synthase A -
LZK98_RS15485 (LZK98_15485) 3278337..3278615 + 279 WP_233783388.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LZK98_RS15490 (LZK98_15490) 3278612..3279004 + 393 WP_233783390.1 type II toxin-antitoxin system VapC family toxin Toxin
LZK98_RS15495 (LZK98_15495) 3279001..3279486 + 486 WP_233783392.1 DNA-deoxyinosine glycosylase -
LZK98_RS15500 (LZK98_15500) 3280149..3280373 + 225 WP_233783394.1 hypothetical protein -
LZK98_RS15505 (LZK98_15505) 3280427..3281389 + 963 WP_233783395.1 class I SAM-dependent methyltransferase -
LZK98_RS15510 (LZK98_15510) 3281446..3282786 + 1341 WP_233783397.1 type VI secretion protein ImpB -
LZK98_RS15515 (LZK98_15515) 3282912..3283289 + 378 WP_233783399.1 hypothetical protein -
LZK98_RS15520 (LZK98_15520) 3283451..3283903 + 453 Protein_3071 leucyl/phenylalanyl-tRNA--protein transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(5-91)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14621.65 Da        Isoelectric Point: 4.9380

>T229944 WP_233783390.1 NZ_CP090059:3278612-3279004 [Sphingomonas cannabina]
MIVDASVLVALLREEPETAWIEPILNANYGTLKMSVANYLEAAIVIDANDDEVLSERLELVIAHFGIELIPMNAYHARIG
REAFNRYGKGRHRARLNYGDCFAYALARGTNEPLLFKGDDFNHTDITLAR

Download         Length: 393 bp

>T229944 NZ_CP124648:c547180-546425 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAGGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGGAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10394.02 Da        Isoelectric Point: 8.6051

>AT229944 WP_233783388.1 NZ_CP090059:3278337-3278615 [Sphingomonas cannabina]
MGVQLNIKSAEARALAEELAEATGESITEAITAALRLRLRQIALEKAKEPNAMREREMAFYRLIRGSRMRWKGAMLSVDH
GDLLYDEHGLPR

Download         Length: 279 bp

>AT229944 NZ_CP124648:c547684-547316 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References