Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4767314..4767915 Replicon chromosome
Accession NZ_CP090028
Organism Serratia ureilytica strain W051

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag LSG14_RS22780 Protein ID WP_025304766.1
Coordinates 4767535..4767915 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag LSG14_RS22775 Protein ID WP_025304767.1
Coordinates 4767314..4767535 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSG14_RS22760 4762978..4764117 - 1140 WP_033645136.1 PLP-dependent aspartate aminotransferase family protein -
LSG14_RS22765 4764197..4764976 - 780 WP_033645137.1 2OG-Fe dioxygenase family protein -
LSG14_RS22770 4765990..4767240 + 1251 WP_047025992.1 valine--pyruvate transaminase -
LSG14_RS22775 4767314..4767535 + 222 WP_025304767.1 ribbon-helix-helix domain-containing protein Antitoxin
LSG14_RS22780 4767535..4767915 + 381 WP_025304766.1 type II toxin-antitoxin system VapC family toxin Toxin
LSG14_RS22785 4767926..4769584 - 1659 WP_033652317.1 putative transporter -
LSG14_RS22790 4769752..4770180 - 429 WP_004933922.1 small heat shock chaperone IbpB -
LSG14_RS22795 4770287..4770700 - 414 WP_004933919.1 small heat shock chaperone IbpA -
LSG14_RS22800 4771010..4771357 + 348 WP_016929593.1 YceK/YidQ family lipoprotein -
LSG14_RS22805 4771388..4772668 - 1281 WP_033645140.1 DUF3748 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T229940 WP_025304766.1 NZ_CP090028:4767535-4767915 [Serratia ureilytica]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T229940 NZ_CP124646:c6676427-6676050 [Pseudomonas aeruginosa]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT229940 WP_025304767.1 NZ_CP090028:4767314-4767535 [Serratia ureilytica]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp

>AT229940 NZ_CP124646:c6676069-6675734 [Pseudomonas aeruginosa]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GSF3

References