Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1616962..1617630 Replicon chromosome
Accession NC_011072
Organism Streptococcus pneumoniae G54

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag SPG_RS08365 Protein ID WP_001132282.1
Coordinates 1617451..1617630 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag SPG_RS08360 Protein ID WP_000961810.1
Coordinates 1616962..1617414 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPG_RS08335 1612851..1613594 - 744 WP_001188201.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
SPG_RS08340 1613596..1614547 - 952 Protein_1601 50S ribosomal protein L11 methyltransferase -
SPG_RS08345 1614685..1615113 - 429 WP_000418162.1 NUDIX hydrolase -
SPG_RS08350 1615094..1616182 - 1089 WP_000719700.1 M50 family metallopeptidase -
SPG_RS08355 1616201..1616671 - 471 WP_000257094.1 DUF3013 family protein -
SPG_RS08360 1616962..1617414 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SPG_RS08365 1617451..1617630 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
SPG_RS08370 1617767..1617946 - 180 WP_001048906.1 hypothetical protein -
SPG_RS08375 1618150..1618350 - 201 WP_000818077.1 hypothetical protein -
SPG_RS08380 1618620..1619891 + 1272 WP_001113215.1 replication-associated recombination protein A -
SPG_RS08390 1620438..1621757 - 1320 WP_000608880.1 glycoside hydrolase family 32 protein -
SPG_RS08395 1621767..1622612 - 846 WP_000819520.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T22994 WP_001132282.1 NC_011072:c1617630-1617451 [Streptococcus pneumoniae G54]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T22994 NC_011072:c1617630-1617451 [Streptococcus pneumoniae G54]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT22994 WP_000961810.1 NC_011072:c1617414-1616962 [Streptococcus pneumoniae G54]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT22994 NC_011072:c1617414-1616962 [Streptococcus pneumoniae G54]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References