Detailed information of TA system TA022993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1092961..1093459
• Replicon: chromosome
• Accession: NC_011072
• Organism: Streptococcus pneumoniae G54

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SPG_RS05615
• Protein ID: WP_012512586.1
• Coordinates: 1092961..1093215 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SPG_RS05620
• Protein ID: WP_012512616.1
• Coordinates: 1093217..1093459 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPG_RS05600	1088234..1090702	-	2469	WP_001153000.1	DNA gyrase subunit A	-
SPG_RS05605	1090896..1091882	+	987	WP_000204727.1	L-lactate dehydrogenase	-
SPG_RS05610	1092171..1092914	-	744	WP_001037000.1	potassium channel family protein	-
SPG_RS05615	1092961..1093215	-	255	WP_012512586.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPG_RS05620	1093217..1093459	-	243	WP_012512616.1	hypothetical protein	Antitoxin
SPG_RS05625	1093550..1094359	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
SPG_RS05630	1094361..1095710	-	1350	WP_000886213.1	cell wall metabolism sensor histidine kinase VicK	-
SPG_RS05635	1095703..1096407	-	705	WP_000722076.1	response regulator transcription factor	-
SPG_RS05640	1096463..1097638	-	1176	WP_000886143.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10144.88 Da
• Isoelectric Point: 10.5987

>T22993 WP_012512586.1 NC_011072:c1093215-1092961 [Streptococcus pneumoniae G54]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVCQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T22993 NC_011072:c1093215-1092961 [Streptococcus pneumoniae G54]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTTGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9214.47 Da
• Isoelectric Point: 4.1375

>AT22993 WP_012512616.1 NC_011072:c1093459-1093217 [Streptococcus pneumoniae G54]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYHEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT22993 NC_011072:c1093459-1093217 [Streptococcus pneumoniae G54]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCATG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA