Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 620846..621515 Replicon chromosome
Accession NZ_CP090028
Organism Serratia ureilytica strain W051

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B4GZI3
Locus tag LSG14_RS02870 Protein ID WP_042785308.1
Coordinates 621093..621515 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8B4GS04
Locus tag LSG14_RS02865 Protein ID WP_019455657.1
Coordinates 620846..621112 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSG14_RS02840 616413..617339 + 927 WP_187048341.1 ribokinase -
LSG14_RS02845 617380..617988 - 609 WP_047573791.1 HD domain-containing protein -
LSG14_RS02850 618172..618846 + 675 WP_033644772.1 hemolysin III family protein -
LSG14_RS02855 618997..619494 + 498 WP_033644774.1 DUF2165 domain-containing protein -
LSG14_RS02860 619533..620525 - 993 WP_042785310.1 tRNA-modifying protein YgfZ -
LSG14_RS02865 620846..621112 + 267 WP_019455657.1 FAD assembly factor SdhE Antitoxin
LSG14_RS02870 621093..621515 + 423 WP_042785308.1 protein YgfX Toxin
LSG14_RS02875 621581..622099 - 519 WP_033635825.1 flavodoxin FldB -
LSG14_RS02880 622206..623105 + 900 WP_233788456.1 site-specific tyrosine recombinase XerD -
LSG14_RS02885 623132..623848 + 717 WP_042785306.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LSG14_RS02890 623855..625588 + 1734 WP_033639478.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16527.59 Da        Isoelectric Point: 10.8114

>T229925 WP_042785308.1 NZ_CP090028:621093-621515 [Serratia ureilytica]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGLLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEQD

Download         Length: 423 bp

>T229925 NZ_CP124641:c148124-147843 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10417.91 Da        Isoelectric Point: 4.7921

>AT229925 WP_019455657.1 NZ_CP090028:620846-621112 [Serratia ureilytica]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT229925 NZ_CP124641:c148348-148121 [Pseudomonas aeruginosa]
ATGAGCACTGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GS04

References