Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 29756..30372 Replicon plasmid p4
Accession NZ_CP090026
Organism Cereibacter azotoformans strain SY5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LV780_RS21840 Protein ID WP_108222584.1
Coordinates 29756..30163 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LV780_RS21845 Protein ID WP_181318578.1
Coordinates 30163..30372 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV780_RS21810 (LV780_21810) 25289..26068 + 780 WP_108222589.1 recombinase family protein -
LV780_RS21815 (LV780_21815) 26369..26770 - 402 WP_108222588.1 hypothetical protein -
LV780_RS21820 (LV780_21820) 26789..27052 - 264 WP_108222587.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
LV780_RS21825 (LV780_21825) 27133..27297 - 165 WP_181318579.1 hypothetical protein -
LV780_RS21830 (LV780_21830) 27480..27788 + 309 WP_108222586.1 hypothetical protein -
LV780_RS21835 (LV780_21835) 28306..29469 - 1164 WP_108222585.1 DUF4268 domain-containing protein -
LV780_RS21840 (LV780_21840) 29756..30163 - 408 WP_108222584.1 tRNA(fMet)-specific endonuclease VapC Toxin
LV780_RS21845 (LV780_21845) 30163..30372 - 210 WP_181318578.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LV780_RS21850 (LV780_21850) 30564..31091 + 528 WP_108222583.1 hypothetical protein -
LV780_RS21855 (LV780_21855) 31255..33036 + 1782 WP_108222582.1 DUF927 domain-containing protein -
LV780_RS21860 (LV780_21860) 33358..33522 + 165 Protein_30 IS5/IS1182 family transposase -
LV780_RS21865 (LV780_21865) 33930..35069 + 1140 WP_205025762.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43861 43861


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14941.25 Da        Isoelectric Point: 7.3602

>T229921 WP_108222584.1 NZ_CP090026:c30163-29756 [Cereibacter azotoformans]
MLRYMLDTNILIYTIRNRPGEVRAKFEAHHGTMCISTVTAMELIFGAQKSQAVERNMAAVEGLLARLDILDLDLAAAQHA
GEIRAQLARAGTPIGPFDVMIAGHARSRGLVLVSNNTREFERVDGLRLENWVQPS

Download         Length: 408 bp

>T229921 NZ_CP124638:c4902691-4902344 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8017.86 Da        Isoelectric Point: 4.2683

>AT229921 WP_181318578.1 NZ_CP090026:c30372-30163 [Cereibacter azotoformans]
MNNRTQAIRLPKSVALPEGTRSVDIVRLGRAWLIVPSQDSWAQWFDEVSSSEDFMERREQPDADERDDL

Download         Length: 210 bp

>AT229921 NZ_CP124638:c4902952-4902701 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References