Detailed information of TA system TA229920

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 1506..2149
• Replicon: plasmid p4
• Accession: NZ_CP090026
• Organism: Cereibacter azotoformans strain SY5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LV780_RS21720
• Protein ID: WP_117345303.1
• Coordinates: 1748..2149 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LV780_RS21715
• Protein ID: WP_108222755.1
• Coordinates: 1506..1748 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LV780_RS21715 (LV780_21715)	1506..1748	+	243	WP_108222755.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LV780_RS21720 (LV780_21720)	1748..2149	+	402	WP_117345303.1	type II toxin-antitoxin system VapC family toxin	Toxin
LV780_RS21725 (LV780_21725)	2287..2982	+	696	WP_108222601.1	recombinase family protein	-
LV780_RS21730 (LV780_21730)	3109..3489	+	381	WP_108222600.1	XRE family transcriptional regulator	-
LV780_RS21735 (LV780_21735)	3449..4225	+	777	WP_108222599.1	RES family NAD+ phosphorylase	-
LV780_RS21740 (LV780_21740)	6611..6904	-	294	WP_108222598.1	CRISPR-associated endonuclease Cas2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..43861	43861

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-47)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14706.71 Da
• Isoelectric Point: 4.8948

>T229920 WP_117345303.1 NZ_CP090026:1748-2149 [Cereibacter azotoformans]
MYLLDTNVISAVRRPDRAPQVAAWLAGRNEADLFLSVITLGEIERGITRQEQGNPAFAADLQAWLDRTMRLFSDRILPFE
AEDARIWGRLSSRIGHNGADLMIAATALARGAVVVTGNVDDFRPTGVRIEDPF

Nucleotide

• Length: 402 bp

>T229920 NZ_CP124638:c4381485-4380898 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8708.84 Da
• Isoelectric Point: 6.4604

>AT229920 WP_108222755.1 NZ_CP090026:1506-1748 [Cereibacter azotoformans]
MWTLQDAKNRFSSVVEAALAGVPQEVSRRGRPAVVVLSVEEYHRLLSGAQGNRGSFADHLMAFPGDGLERAEVVPRDVGF

Nucleotide

• Length: 243 bp

>AT229920 NZ_CP124638:c4380831-4379977 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGTGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAGCAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA