Detailed information of TA system TA022992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 284440..285088
• Replicon: chromosome
• Accession: NC_011071
• Organism: Stenotrophomonas maltophilia R551-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4ST98
• Locus tag: SMAL_RS01195
• Protein ID: WP_012509779.1
• Coordinates: 284440..284727 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: B4ST99
• Locus tag: SMAL_RS01200
• Protein ID: WP_012509780.1
• Coordinates: 284786..285088 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMAL_RS01165	280402..281148	-	747	WP_041864460.1	zinc-dependent peptidase	-
SMAL_RS01170	281157..281441	-	285	WP_012509775.1	hypothetical protein	-
SMAL_RS01175	281586..282554	+	969	WP_012509776.1	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor	-
SMAL_RS01180	282551..283282	+	732	WP_012509777.1	type III pantothenate kinase	-
SMAL_RS01185	283292..284140	+	849	WP_012509778.1	SPOR domain-containing protein	-
SMAL_RS01195	284440..284727	+	288	WP_012509779.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SMAL_RS01200	284786..285088	+	303	WP_012509780.1	putative addiction module antidote protein	Antitoxin
SMAL_RS21000	285149..285634	+	486	WP_157628455.1	hypothetical protein	-
SMAL_RS01210	285891..286811	+	921	WP_004137058.1	arginase	-
SMAL_RS01215	286974..287111	+	138	WP_008266021.1	entericidin A/B family lipoprotein	-
SMAL_RS01220	287315..287536	+	222	WP_004137109.1	CsbD family protein	-
SMAL_RS01225	287610..288410	-	801	WP_012509781.1	hypothetical protein	-
SMAL_RS01230	288519..289811	+	1293	WP_004137142.1	tryptophan--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-90)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-95)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10835.41 Da
• Isoelectric Point: 10.8940

>T22992 WP_012509779.1 NC_011071:284440-284727 [Stenotrophomonas maltophilia R551-3]
MKIQRTRQFATWIDALKDVTGRARILARIGRLSEGHLGDHRYLADGVSELRIDVGPGYRVYYTQRGRQWVILLAGGDKGS
QQRDIEKAREIARAL

Nucleotide

• Length: 288 bp

>T22992 NC_011071:284440-284727 [Stenotrophomonas maltophilia R551-3]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGGGCGCGCTCGCATCCTGGC
CCGCATCGGTCGGCTCAGCGAAGGCCATCTGGGCGATCACCGCTATCTGGCCGATGGCGTTTCCGAACTGCGCATCGATG
TGGGACCGGGTTACCGCGTGTACTACACCCAGCGCGGCAGGCAGTGGGTGATTCTGCTGGCTGGCGGCGACAAGGGTTCA
CAGCAACGCGATATCGAGAAGGCCAGGGAGATTGCGCGTGCCCTGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10734.37 Da
• Isoelectric Point: 8.0343

>AT22992 WP_012509780.1 NC_011071:284786-285088 [Stenotrophomonas maltophilia R551-3]
MVIKKKVELKAFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAA

Nucleotide

• Length: 303 bp

>AT22992 NC_011071:284786-285088 [Stenotrophomonas maltophilia R551-3]
ATGGTCATCAAGAAGAAAGTTGAACTCAAAGCATTTGACGTGGCCGAGCACCTTCGCACACCGGAGGAGATGGCGGCCTA
TCTCGATGCCTGCATCGAAGAAAGCGATGGCGATTCTGCGTTCATTGCCAAGGCGCTCGGCGACATCGCGCGCGCTCAAG
GGATGAGCAAGGTCGCACGAGCGGCGGGCCTCTCGCGTGAGAGTCTGTATCGCGCACTGTCGGGCGAGCGCAGCCCTGAT
TTTGCGACCATCCTCAAAGTGACCCGCGCCTTGGGTGTTCGCCTGCATGCCAGCGCAGCATAA

Structures

Toxin

• AlphaFold DB: B4ST98

Antitoxin

• AlphaFold DB: B4ST99