Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 356374..356833 Replicon chromosome
Accession NZ_CP090007
Organism Streptococcus salivarius strain SALI-10

Toxin (Protein)


Gene name relE Uniprot ID F8LI54
Locus tag LV497_RS01620 Protein ID WP_013990357.1
Coordinates 356374..356628 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8LI53
Locus tag LV497_RS01625 Protein ID WP_013990356.1
Coordinates 356618..356833 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV497_RS01595 (LV497_01595) 351861..352616 + 756 WP_073687033.1 hypothetical protein -
LV497_RS01600 (LV497_01600) 353094..353972 - 879 WP_245085009.1 HAMP domain-containing sensor histidine kinase -
LV497_RS01605 (LV497_01605) 353972..354655 - 684 WP_245085011.1 response regulator transcription factor -
LV497_RS01610 (LV497_01610) 354819..355451 - 633 WP_245085014.1 nitroreductase family protein -
LV497_RS01615 (LV497_01615) 355543..356229 - 687 WP_245085016.1 YoaK family protein -
LV497_RS01620 (LV497_01620) 356374..356628 - 255 WP_013990357.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LV497_RS01625 (LV497_01625) 356618..356833 - 216 WP_013990356.1 DUF6290 family protein Antitoxin
LV497_RS01630 (LV497_01630) 356966..357808 - 843 WP_245085020.1 aldo/keto reductase -
LV497_RS01635 (LV497_01635) 357942..358943 - 1002 WP_245085023.1 UDP-glucose 4-epimerase GalE -
LV497_RS01640 (LV497_01640) 359073..360683 - 1611 WP_245085025.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-57)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9862.61 Da        Isoelectric Point: 11.1183

>T229915 WP_013990357.1 NZ_CP090007:c356628-356374 [Streptococcus salivarius]
MTYKIVPTPKFAKSFKKLDPFVRKQIKSYLNRVTDNPRAKGKALVANRTGQWRYRIGAYRVIVNIQDNELIILALEVGHR
RDIY

Download         Length: 255 bp

>T229915 NZ_CP124633:49587-49886 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCTAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATTCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8016.98 Da        Isoelectric Point: 3.8852

>AT229915 WP_013990356.1 NZ_CP090007:c356833-356618 [Streptococcus salivarius]
MTTITLKVSEADKKFMQAIAKFEGVSLSELIRTKTLDAIEDEYDARVADLALAEYEDYLENGGEVLNWDDL

Download         Length: 216 bp

>AT229915 NZ_CP124633:49883-50173 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8LI54

Antitoxin

Source ID Structure
AlphaFold DB F8LI53

References