Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 460615..461263 Replicon chromosome
Accession NZ_CP090006
Organism Virgibacillus halodenitrificans strain ASH15

Toxin (Protein)


Gene name mazF Uniprot ID A0A6L8JWB3
Locus tag LWC06_RS02420 Protein ID WP_019379217.1
Coordinates 460904..461263 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag LWC06_RS02415 Protein ID WP_233880187.1
Coordinates 460615..460899 (+) Length 95 a.a.

Genomic Context

LWC06_RS02395LWC06_RS02400LWC06_RS02405LWC06_RS02410LWC06_RS02415LWC06_RS02420LWC06_RS02425LWC06_RS02430LWC06_RS02435LWC06_RS02440LWC06_RS02445LWC06_RS02450LWC06_RS02455
Location: 456100..456459 (360 bp)
Type: Others
Protein ID: WP_233880183.1
Location: 456519..458039 (1521 bp)
Type: Others
Protein ID: WP_233880184.1
Location: 458127..459137 (1011 bp)
Type: Others
Protein ID: WP_233880185.1
Location: 459328..460452 (1125 bp)
Type: Others
Protein ID: WP_233880186.1
Location: 460615..460899 (285 bp)
Type: Antitoxin
Protein ID: WP_233880187.1
Location: 460904..461263 (360 bp)
Type: Toxin
Protein ID: WP_019379217.1
Location: 461624..462493 (870 bp)
Type: Others
Protein ID: WP_233880189.1
Location: 462499..462855 (357 bp)
Type: Others
Protein ID: WP_040954281.1
Location: 462858..463259 (402 bp)
Type: Others
Protein ID: WP_233880190.1
Location: 463367..464380 (1014 bp)
Type: Others
Protein ID: WP_233880191.1
Location: 464487..464819 (333 bp)
Type: Others
Protein ID: WP_060681899.1
Location: 464819..465295 (477 bp)
Type: Others
Protein ID: WP_019379211.1
Location: 465267..466058 (792 bp)
Type: Others
Protein ID: WP_060681900.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LWC06_RS02395456100..456459+360WP_233880183.1holo-ACP synthase-
LWC06_RS02400456519..458039+1521WP_233880184.1NAD(P)H-hydrate dehydratase-
LWC06_RS02405458127..459137+1011WP_233880185.1outer membrane lipoprotein carrier protein LolA-
LWC06_RS02410459328..460452+1125WP_233880186.1alanine racemase-
LWC06_RS02415460615..460899+285WP_233880187.1antitoxinAntitoxin
LWC06_RS02420460904..461263+360WP_019379217.1type II toxin-antitoxin system PemK/MazF family toxinToxin
LWC06_RS02425461624..462493+870WP_233880189.1RsbT co-antagonist protein RsbRA-
LWC06_RS02430462499..462855+357WP_040954281.1STAS domain-containing protein-
LWC06_RS02435462858..463259+402WP_233880190.1anti-sigma regulatory factor-
LWC06_RS02440463367..464380+1014WP_233880191.1PP2C family protein-serine/threonine phosphatase-
LWC06_RS02445464487..464819+333WP_060681899.1STAS domain-containing protein-
LWC06_RS02450464819..465295+477WP_019379211.1anti-sigma B factor RsbW-
LWC06_RS02455465267..466058+792WP_060681900.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13377.53 Da        Isoelectric Point: 8.4940

>T229914 WP_019379217.1 NZ_CP090006:460904-461263 [Virgibacillus halodenitrificans]
MIVQRGEVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKRYGFDRNSVILLEQI
RTLDKQRLTDKITKLDAEMMNKINQALEISLGLKDMYDH

Download         Length: 360 bp

>T229914 NZ_CP124632:c6359755-6359477 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10888.19 Da        Isoelectric Point: 4.2057

>AT229914 WP_233880187.1 NZ_CP090006:460615-460899 [Virgibacillus halodenitrificans]
MSESLQEILVKIPKNLLNEVDGLMRYENSDLSDFICQATRSYLQDKKDEHIQQFRETMQKGYEEMGRINLTIASEAFQAE
EEAENTLERSVIGV

Download         Length: 285 bp

>AT229914 NZ_CP124632:c6359465-6359160 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAATGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6L8JWB3

Antitoxin

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Source
ID
Structure
No matching records found

References