Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2358997..2359913 Replicon chromosome
Accession NZ_CP090005
Organism Providencia rettgeri strain PROV_UAMS_01

Toxin (Protein)


Gene name - Uniprot ID A0A6G6PK18
Locus tag LV777_RS10495 Protein ID WP_004910825.1
Coordinates 2359455..2359913 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6G6PJY5
Locus tag LV777_RS10490 Protein ID WP_004910826.1
Coordinates 2358997..2359458 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV777_RS10465 (LV777_10470) 2355197..2355838 - 642 WP_164528843.1 leucine efflux protein LeuE -
LV777_RS10470 (LV777_10475) 2356324..2357178 + 855 WP_209101489.1 AraC family transcriptional regulator -
LV777_RS10475 (LV777_10480) 2357237..2357938 + 702 WP_004910829.1 AzlC family ABC transporter permease -
LV777_RS10480 (LV777_10485) 2357935..2358249 + 315 WP_004910828.1 AzlD domain-containing protein -
LV777_RS10485 (LV777_10490) 2358441..2358908 + 468 WP_248445203.1 DUF1456 family protein -
LV777_RS10490 (LV777_10495) 2358997..2359458 + 462 WP_004910826.1 DUF2384 domain-containing protein Antitoxin
LV777_RS10495 (LV777_10500) 2359455..2359913 + 459 WP_004910825.1 RES domain-containing protein Toxin
LV777_RS10500 (LV777_10505) 2359914..2360804 - 891 WP_117161936.1 LysR family transcriptional regulator -
LV777_RS10505 (LV777_10510) 2360850..2361809 - 960 WP_198634874.1 acetyl-CoA carboxylase carboxyl transferase subunit alpha -
LV777_RS10510 (LV777_10515) 2361915..2362337 - 423 WP_004910820.1 helix-turn-helix domain-containing protein -
LV777_RS10515 (LV777_10520) 2362368..2362895 - 528 WP_004910818.1 GNAT family N-acetyltransferase -
LV777_RS10520 (LV777_10525) 2362912..2364378 - 1467 WP_109912197.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-146)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(99-150)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17188.77 Da        Isoelectric Point: 6.2048

>T229912 WP_004910825.1 NZ_CP090005:2359455-2359913 [Providencia rettgeri]
MILYRLVKSSFIHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDLLLNQFSLLSIDINDRYVMKLSLD
HLPTDWQQDPAPTSTMDIGTTWLNNQDSLVLLIPSCIIPYEYNAIINPLHPQFQKAIHTVKPLDFSVDPRLA

Download         Length: 459 bp

>T229912 NZ_CP124632:c6148057-6147767 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17060.54 Da        Isoelectric Point: 9.9140

>AT229912 WP_004910826.1 NZ_CP090005:2358997-2359458 [Providencia rettgeri]
MRNYIPTTPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAAGDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Download         Length: 462 bp

>AT229912 NZ_CP124632:c6148353-6148054 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCTAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATTCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6PK18

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6PJY5

References