Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1459077..1459734 Replicon chromosome
Accession NZ_CP090005
Organism Providencia rettgeri strain PROV_UAMS_01

Toxin (Protein)


Gene name cptA Uniprot ID A0A6G6PHM2
Locus tag LV777_RS06300 Protein ID WP_042851636.1
Coordinates 1459324..1459734 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6G6PHM9
Locus tag LV777_RS06295 Protein ID WP_004913039.1
Coordinates 1459077..1459343 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV777_RS06280 (LV777_06280) 1456073..1456969 - 897 WP_164528562.1 hypothetical protein -
LV777_RS06285 (LV777_06285) 1457214..1457834 - 621 WP_248445592.1 HD domain-containing protein -
LV777_RS06290 (LV777_06290) 1457846..1458829 - 984 WP_110732097.1 tRNA-modifying protein YgfZ -
LV777_RS06295 (LV777_06295) 1459077..1459343 + 267 WP_004913039.1 FAD assembly factor SdhE Antitoxin
LV777_RS06300 (LV777_06300) 1459324..1459734 + 411 WP_042851636.1 protein YgfX Toxin
LV777_RS06305 (LV777_06305) 1459824..1460342 - 519 WP_004913034.1 flavodoxin FldB -
LV777_RS06310 (LV777_06310) 1460460..1461362 + 903 WP_109912915.1 site-specific tyrosine recombinase XerD -
LV777_RS06315 (LV777_06315) 1461384..1462088 + 705 WP_109912946.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LV777_RS06320 (LV777_06320) 1462098..1463831 + 1734 WP_123382309.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15612.59 Da        Isoelectric Point: 10.7733

>T229911 WP_042851636.1 NZ_CP090005:1459324-1459734 [Providencia rettgeri]
VVLWKSNLSISWKTQLFSTCVHGVIGMFLLLTPWSPGNSMIWLPLLVVVVASWAKSQKNISKIKGVAVLVNGNKLQWKKN
EWRILKAPWLTRYGILLTLEALQGKPQKIHLWVAKDALSEENWRNLNQLLLQYPDI

Download         Length: 411 bp

>T229911 NZ_CP124632:c6028944-6028762 [Pseudomonas aeruginosa]
ATGCGGAGTAGGGAAGTGATTGATTTGCTGTTGGAGGATGGCTGGTATGAAGTGGCGGTGAAAGGTAGCCACCACCAGTT
CAAACATCCTTCAAAGCCTGGAAAGGTGACGGTTCAACATCCGTCCTCGACGATACCGAAAGGAACCCTGAACAACATAC
TGAAACAAGCCGGCCTCAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10674.24 Da        Isoelectric Point: 4.8780

>AT229911 WP_004913039.1 NZ_CP090005:1459077-1459343 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDNLTTQDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMIKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT229911 NZ_CP124632:c6028734-6028330 [Pseudomonas aeruginosa]
ATGAAATTCCCCGTGGTGTTACACAAAGACCCTGATTCTGACTATGGCGTGACTGTGCCCGATGTGCCGGGTTGCTTCTC
TGCCGGCGCTACGGTGTCCGAGGCCCTGGCCAATGTAGAAGAGGCGCTGGCCTTGCACTTCGAAGGCTTGGTTACGGACG
GCGAAGAGCTACCCCAGCCGCAGGACGTTGACGCCCATATGAAGAATCCGGACTTCGAAGGTGGCGTATGGGCGGTGGTT
GACTTCGACGTGACCCCGTACCTGGGCAAGGCCGTACGCTTTAATGCGACGCTCCCGGAACACCTTCTGCAGCGGATCGA
TGAGCGCGTGAAGGTGGATAAGCGCTATCAGTCTCGGTCGGGCTTTCTGGCAACAGCGGCGATGCGCGAACTGTCAGTGG
CGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6PHM2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6PHM9

References