Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Xre
Location 970589..971288 Replicon chromosome
Accession NZ_CP090005
Organism Providencia rettgeri strain PROV_UAMS_01

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LV777_RS04195 Protein ID WP_248445555.1
Coordinates 970899..971288 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LV777_RS04190 Protein ID WP_248445554.1
Coordinates 970589..970906 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV777_RS04160 (LV777_04160) 966075..966977 + 903 WP_248445548.1 integrase domain-containing protein -
LV777_RS04165 (LV777_04165) 966967..967608 + 642 WP_282561333.1 SGNH/GDSL hydrolase family protein -
LV777_RS04170 (LV777_04170) 968090..968626 + 537 WP_248445550.1 hypothetical protein -
LV777_RS04175 (LV777_04175) 968716..969120 + 405 WP_248445551.1 hypothetical protein -
LV777_RS04180 (LV777_04180) 969247..970221 + 975 WP_248445552.1 zincin-like metallopeptidase domain-containing protein -
LV777_RS04185 (LV777_04185) 970231..970536 + 306 WP_248445553.1 TA system toxin CbtA family protein -
LV777_RS04190 (LV777_04190) 970589..970906 - 318 WP_248445554.1 helix-turn-helix domain-containing protein Antitoxin
LV777_RS04195 (LV777_04195) 970899..971288 - 390 WP_248445555.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LV777_RS04200 (LV777_04200) 971566..973131 + 1566 WP_248445556.1 TraI domain-containing protein -
LV777_RS19460 973703..974206 + 504 WP_282561334.1 site-specific integrase -
LV777_RS04215 (LV777_04215) 974716..975789 - 1074 WP_109911957.1 membrane-bound lytic murein transglycosylase MltC -
LV777_RS04220 (LV777_04220) 975844..976113 - 270 WP_004914180.1 oxidative damage protection protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 919767..974504 54737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(3-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-90)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14379.69 Da        Isoelectric Point: 6.3578

>T229910 WP_248445555.1 NZ_CP090005:c971288-970899 [Providencia rettgeri]
VGIYLTPEFEEERRNARISNAILCKAAKAIFSGLPGDPLGKFTYKKRLGLPGVGAKDGARSIVFFNNGENLFFFDMYLKS
ELSKKKGKELEADEINAYCNIAKDFIAMSSVMIKTLLTDKELIEVICDD

Download         Length: 390 bp

>T229910 NZ_CP124632:c5355506-5354751 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11725.67 Da        Isoelectric Point: 11.0022

>AT229910 WP_248445554.1 NZ_CP090005:c970906-970589 [Providencia rettgeri]
MTERLKRIQGMAERYNKLGVVRNETVAVIDAAVAARKIPAVRTMTGSQIKEVRTRYNMSQAALAMTTGMSVESVSKWERN
ESKPNKAALRIINIIDDKGPQVFMS

Download         Length: 318 bp

>AT229910 NZ_CP124632:c5356009-5355641 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References