Detailed information of TA system TA022991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 113031..114614
• Replicon: chromosome
• Accession: NC_011071
• Organism: Stenotrophomonas maltophilia R551-3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: B4SRS8
• Locus tag: SMAL_RS00465
• Protein ID: WP_012509672.1
• Coordinates: 113031..114353 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: M5CTC8
• Locus tag: SMAL_RS00470
• Protein ID: WP_004134030.1
• Coordinates: 114357..114614 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMAL_RS00450	108437..110071	-	1635	WP_012509669.1	TldD/PmbA family protein	-
SMAL_RS00455	110099..111730	-	1632	WP_012509670.1	TldD/PmbA family protein	-
SMAL_RS00460	112416..113030	+	615	WP_012509671.1	DUF938 domain-containing protein	-
SMAL_RS00465	113031..114353	-	1323	WP_012509672.1	type II toxin-antitoxin system HipA family toxin	Toxin
SMAL_RS00470	114357..114614	-	258	WP_004134030.1	helix-turn-helix transcriptional regulator	Antitoxin
SMAL_RS00475	114772..118458	-	3687	WP_012509673.1	indolepyruvate ferredoxin oxidoreductase family protein	-
SMAL_RS00480	118628..119263	+	636	WP_012509674.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (19-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 48894.60 Da
• Isoelectric Point: 6.7711

>T22991 WP_012509672.1 NC_011071:c114353-113031 [Stenotrophomonas maltophilia R551-3]
MGTLRVWMNGVEVALWDDVRSGSSRLSYVDSWISSAQSRPLSLSLPLLPEGESHRGNVVNNYFDNLLPDNGVIRNRIRDR
FSTRSSDTFDLLEAIGRDCVGAAQLLPLSHTPGDIQQITCEALDESGVAAILRQVTTGNLPGAPTSDDAFRISIAGAQEK
TGLLLHAGQWCIPTGSTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMQLLSAFGIPVANTQMGRFKDERALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVTIMDLLRQSEHFKDRETFFKTQILFWMLAATDGHAKNFSVYLE
ADGRFRLTPVYDVLSVHPILGRGPNQLDPRNAQLAMSVQGKNHHRKLHLVRRRHWNETARACGVADGAEPWIEALIAAVE
PAIEQVTRQLPSDFPVNVSEPIFNGLRAAAARLSSMSPDA

Nucleotide

• Length: 1323 bp

>T22991 NC_011071:c114353-113031 [Stenotrophomonas maltophilia R551-3]
ATGGGTACGCTGCGGGTCTGGATGAATGGTGTCGAGGTCGCGCTCTGGGATGATGTCCGGAGCGGCTCTTCCCGGCTTTC
GTACGTCGACTCGTGGATCAGCTCCGCCCAGTCCCGGCCGTTGTCACTCTCACTGCCCCTGCTCCCGGAGGGCGAGAGCC
ATCGGGGCAATGTCGTCAACAACTACTTCGACAACCTTCTTCCCGACAACGGTGTCATCCGCAACCGGATCCGCGACAGG
TTCTCCACGCGCAGCAGCGACACATTCGATCTTCTCGAAGCCATTGGCCGGGATTGCGTCGGCGCAGCGCAACTGCTGCC
GCTTTCGCATACACCGGGGGACATCCAGCAGATTACGTGCGAAGCGTTGGACGAATCAGGCGTCGCTGCGATCCTGCGTC
AGGTGACGACAGGGAACCTGCCTGGCGCACCCACCAGTGATGATGCGTTCCGCATATCCATCGCCGGTGCGCAGGAGAAG
ACGGGACTTCTGCTGCATGCTGGCCAGTGGTGCATTCCTACCGGCAGTACCCCATCCACCCATATCTTCAAGCTGCCGCT
TGGCATTGTGGGCAACATGCGGGCGGACATGCACCAATCCGTCGAGAACGAATGGCTGTGCATGCAGCTGCTTTCCGCCT
TTGGAATCCCCGTTGCGAATACGCAGATGGGACGCTTCAAGGACGAACGCGCGCTCATTGTGGAGCGATTCGACCGCCGC
CTTTCTGCGGATCGCCGGTGGTGGCTGCGGCTGCCGCAGGAAGACATGTGCCAGGTCTTCGGTCTGCCCGCCGCCAGGAA
GTATGAATCCGATGGCGGCCCAGGCATCGTGACCATCATGGATCTGCTTCGACAATCCGAGCATTTCAAGGATCGCGAGA
CCTTCTTCAAGACGCAGATTCTTTTCTGGATGTTGGCTGCAACCGATGGACATGCCAAGAACTTCAGTGTCTACCTCGAA
GCCGATGGACGCTTCCGCCTGACGCCCGTCTACGACGTATTGTCGGTGCATCCCATCCTGGGCAGGGGGCCAAACCAGCT
CGACCCGCGGAATGCACAGCTCGCCATGTCCGTCCAGGGCAAGAACCACCACCGGAAGCTGCACCTTGTGCGACGACGCC
ACTGGAACGAAACCGCACGCGCCTGTGGTGTCGCTGATGGTGCAGAGCCGTGGATCGAAGCGCTGATCGCAGCCGTCGAA
CCCGCCATCGAGCAGGTCACGCGTCAGCTCCCAAGTGATTTCCCCGTAAACGTGTCCGAACCCATTTTCAACGGGCTGCG
CGCTGCAGCGGCACGCCTTTCCAGCATGTCGCCGGACGCCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9550.01 Da
• Isoelectric Point: 12.0740

>AT22991 WP_004134030.1 NC_011071:c114614-114357 [Stenotrophomonas maltophilia R551-3]
MDRPLHTVRTPQQLAPLMRAFRRQAGLSQAQLAAQLGISRQAVGALERDPASASFERLMRVWAVLGLEVRLQQRSPPETT
STLEW

Nucleotide

• Length: 258 bp

>AT22991 NC_011071:c114614-114357 [Stenotrophomonas maltophilia R551-3]
ATGGACAGGCCGCTGCACACGGTGAGGACACCTCAACAACTGGCACCGCTGATGCGTGCGTTCAGGCGCCAGGCGGGCCT
GAGCCAAGCGCAGTTGGCGGCACAGCTCGGCATAAGCCGCCAGGCAGTAGGCGCATTGGAGCGCGACCCGGCATCGGCAA
GCTTCGAACGGCTGATGCGGGTCTGGGCAGTGCTGGGTCTGGAAGTCAGATTGCAGCAGCGAAGTCCCCCGGAGACAACG
TCAACGTTGGAGTGGTGA

Structures

Toxin

• AlphaFold DB: B4SRS8

Antitoxin

• AlphaFold DB: M5CTC8