Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 811482..811959 Replicon chromosome
Accession NZ_CP090001
Organism Staphylococcus aureus strain RN6390

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag LV622_RS03875 Protein ID WP_000052078.1
Coordinates 811482..811670 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag LV622_RS03880 Protein ID WP_001059690.1
Coordinates 811699..811959 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV622_RS03845 (LV622_03845) 807523..807993 + 471 WP_000824472.1 hypothetical protein -
LV622_RS03850 (LV622_03850) 808334..809020 + 687 WP_001548082.1 thermonuclease family protein -
LV622_RS03855 (LV622_03855) 809377..809577 + 201 WP_001059082.1 cold-shock protein -
LV622_RS03860 (LV622_03860) 810073..810291 - 219 WP_000005886.1 hypothetical protein -
LV622_RS03865 (LV622_03865) 810353..810637 - 285 WP_001004395.1 hypothetical protein -
LV622_RS03870 (LV622_03870) 810725..811294 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
LV622_RS03875 (LV622_03875) 811482..811670 - 189 WP_000052078.1 hypothetical protein Toxin
LV622_RS03880 (LV622_03880) 811699..811959 - 261 WP_001059690.1 hypothetical protein Antitoxin
LV622_RS03885 (LV622_03885) 812300..812503 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
LV622_RS03890 (LV622_03890) 812500..812736 - 237 WP_000368687.1 hypothetical protein -
LV622_RS03895 (LV622_03895) 812961..813542 + 582 WP_001140693.1 histidine phosphatase family protein -
LV622_RS03900 (LV622_03900) 813615..814232 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
LV622_RS03905 (LV622_03905) 814387..814881 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
LV622_RS03910 (LV622_03910) 815280..815702 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
LV622_RS03915 (LV622_03915) 815850..816566 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(8-67)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T229898 WP_000052078.1 NZ_CP090001:c811670-811482 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T229898 NZ_CP124626:3212998-3213753 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT229898 WP_001059690.1 NZ_CP090001:c811959-811699 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT229898 NZ_CP124626:3212495-3212863 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References