Detailed information of TA system TA229889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2437754..2438424
• Replicon: chromosome
• Accession: NZ_CP089999
• Organism: Xanthomonas translucens strain B8GF

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LV507_RS11020
• Protein ID: WP_058361064.1
• Coordinates: 2437754..2438173 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2S7EM03
• Locus tag: LV507_RS11025
• Protein ID: WP_003473422.1
• Coordinates: 2438170..2438424 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LV507_RS10975 (LV507_10975)	2432789..2433022	+	234	WP_003472509.1	hypothetical protein	-
LV507_RS10980 (LV507_10980)	2433026..2433904	+	879	WP_058361060.1	helicase RepA family protein	-
LV507_RS10985 (LV507_10985)	2433876..2434265	+	390	Protein_2165	replication protein C, IncQ-type	-
LV507_RS10990 (LV507_10990)	2434233..2434601	-	369	WP_058361061.1	conjugal transfer transcriptional regulator TraJ	-
LV507_RS10995 (LV507_10995)	2434604..2434888	-	285	WP_058361062.1	hypothetical protein	-
LV507_RS11000 (LV507_11000)	2434900..2435142	-	243	WP_033981742.1	type I toxin-antitoxin system ptaRNA1 family toxin	-
LV507_RS11005 (LV507_11005)	2435256..2436656	-	1401	WP_058361063.1	P-type conjugative transfer protein TrbL	-
LV507_RS11010 (LV507_11010)	2436658..2436816	-	159	WP_153476784.1	hypothetical protein	-
LV507_RS11015 (LV507_11015)	2436827..2437597	-	771	WP_058361066.1	P-type conjugative transfer protein TrbJ	-
LV507_RS11020 (LV507_11020)	2437754..2438173	-	420	WP_058361064.1	type II toxin-antitoxin system VapC family toxin	Toxin
LV507_RS11025 (LV507_11025)	2438170..2438424	-	255	WP_003473422.1	hypothetical protein	Antitoxin
LV507_RS11030 (LV507_11030)	2438836..2439117	-	282	WP_058361065.1	TraK family protein	-
LV507_RS11035 (LV507_11035)	2439734..2440234	-	501	Protein_2175	replication protein C, IncQ-type	-
LV507_RS11045 (LV507_11045)	2441922..2442887	+	966	WP_065898826.1	IS1595 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2423621..2444889	21268

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14945.19 Da
• Isoelectric Point: 4.9167

>T229889 WP_058361064.1 NZ_CP089999:c2438173-2437754 [Xanthomonas translucens]
MIVLDTNVVSEAMKPEPDPAVRAWLNEQVAETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFSERVLMFDTE
AARNYAELAVKARIAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHR

Nucleotide

• Length: 420 bp

>T229889 NZ_CP124624:c4902994-4902647 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9507.88 Da
• Isoelectric Point: 7.2071

>AT229889 WP_003473422.1 NZ_CP089999:c2438424-2438170 [Xanthomonas translucens]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSQKRIRMGDALAELGRRVGLTNDDFAVLDQVRDKVPAEP
MRFE

Nucleotide

• Length: 255 bp

>AT229889 NZ_CP124624:c4903255-4903004 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A2S7EM03