Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 283605..284253 Replicon chromosome
Accession NZ_CP089997
Organism Cytobacillus spongiae strain CY-G

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LS684_RS01545 Protein ID WP_233809310.1
Coordinates 283903..284253 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag LS684_RS01540 Protein ID WP_233809309.1
Coordinates 283605..283898 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LS684_RS01520 (LS684_01520) 279375..280094 - 720 WP_233809301.1 rhomboid family intramembrane serine protease -
LS684_RS01525 (LS684_01525) 280385..280738 + 354 WP_233809303.1 holo-ACP synthase -
LS684_RS01530 (LS684_01530) 280934..281953 + 1020 WP_233809305.1 outer membrane lipoprotein carrier protein LolA -
LS684_RS01535 (LS684_01535) 282266..283429 + 1164 WP_233809307.1 alanine racemase -
LS684_RS01540 (LS684_01540) 283605..283898 + 294 WP_233809309.1 antitoxin endoai Antitoxin
LS684_RS01545 (LS684_01545) 283903..284253 + 351 WP_233809310.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LS684_RS01550 (LS684_01550) 284599..285432 + 834 WP_233811512.1 RsbT co-antagonist protein RsbRA -
LS684_RS01555 (LS684_01555) 285429..285785 + 357 WP_233809312.1 STAS domain-containing protein -
LS684_RS01560 (LS684_01560) 285788..286189 + 402 WP_233809314.1 anti-sigma regulatory factor -
LS684_RS01565 (LS684_01565) 286201..287211 + 1011 WP_233809316.1 PP2C family protein-serine/threonine phosphatase -
LS684_RS01570 (LS684_01570) 287275..287604 + 330 WP_233809318.1 anti-sigma factor antagonist -
LS684_RS01575 (LS684_01575) 287604..288077 + 474 WP_233809320.1 anti-sigma B factor RsbW -
LS684_RS01580 (LS684_01580) 288055..288846 + 792 WP_233809322.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12963.95 Da        Isoelectric Point: 5.1663

>T229888 WP_233809310.1 NZ_CP089997:283903-284253 [Cytobacillus spongiae]
MNVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQVSLGLIDF

Download         Length: 351 bp

>T229888 NZ_CP124624:c4508988-4508233 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGGAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11286.80 Da        Isoelectric Point: 5.9080

>AT229888 WP_233809309.1 NZ_CP089997:283605-283898 [Cytobacillus spongiae]
VSESSATTEIMVELPQQLLSELDVYISSEQVNRNEFIKHATQKYLRERKKRQIRESMRRGYMEMAKINLMIASEAFQAEY
EAENTVTNRVERLVSGG

Download         Length: 294 bp

>AT229888 NZ_CP124624:c4509491-4509123 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References