Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1783411..1784386 Replicon chromosome
Accession NZ_CP089993
Organism Bacillus anthracis strain BF5

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag LKW29_RS09245 Protein ID WP_002036394.1
Coordinates 1783411..1784148 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag LKW29_RS09250 Protein ID WP_000588712.1
Coordinates 1784261..1784386 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKW29_RS09225 (LKW29_09225) 1779139..1779921 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
LKW29_RS09230 (LKW29_09230) 1780043..1781728 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
LKW29_RS09235 (LKW29_09235) 1781835..1782317 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
LKW29_RS09240 (LKW29_09240) 1782485..1783222 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
LKW29_RS09245 (LKW29_09245) 1783411..1784148 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
LKW29_RS09250 (LKW29_09250) 1784261..1784386 + 126 WP_000588712.1 hypothetical protein Antitoxin
LKW29_RS09255 (LKW29_09255) 1784463..1784639 + 177 WP_000852614.1 hypothetical protein -
LKW29_RS09260 (LKW29_09260) 1784676..1784957 - 282 WP_001041555.1 hypothetical protein -
LKW29_RS09265 (LKW29_09265) 1785234..1785470 - 237 WP_001021688.1 hypothetical protein -
LKW29_RS28670 1785607..1785732 + 126 WP_000694311.1 hypothetical protein -
LKW29_RS09270 (LKW29_09270) 1786128..1787597 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
LKW29_RS09275 (LKW29_09275) 1788161..1788631 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T229884 WP_002036394.1 NZ_CP089993:1783411-1784148 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T229884 NZ_CP124622:c5505757-5505479 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT229884 WP_000588712.1 NZ_CP089993:1784261-1784386 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT229884 NZ_CP124622:c5505467-5505162 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAATGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References