229870

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2983424..2984081 Replicon chromosome
Accession NZ_CP089989
Organism Klebsiella pneumoniae strain LZKP00003

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LUR00_RS14375 Protein ID WP_002916310.1
Coordinates 2983671..2984081 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LUR00_RS14370 Protein ID WP_002916312.1
Coordinates 2983424..2983690 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUR00_RS14345 (LUR00_14345) 2978632..2980065 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
LUR00_RS14350 (LUR00_14350) 2980184..2980912 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LUR00_RS14355 (LUR00_14355) 2980962..2981273 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LUR00_RS14360 (LUR00_14360) 2981437..2982096 + 660 WP_102011713.1 hemolysin III family protein -
LUR00_RS14365 (LUR00_14365) 2982195..2983178 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
LUR00_RS14370 (LUR00_14370) 2983424..2983690 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LUR00_RS14375 (LUR00_14375) 2983671..2984081 + 411 WP_002916310.1 protein YgfX Toxin
LUR00_RS14380 (LUR00_14380) 2984088..2984609 - 522 WP_004144730.1 flavodoxin FldB -
LUR00_RS14385 (LUR00_14385) 2984710..2985606 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LUR00_RS14390 (LUR00_14390) 2985629..2986342 + 714 WP_101862174.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LUR00_RS14395 (LUR00_14395) 2986348..2988081 + 1734 WP_102011714.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T229870 WP_002916310.1 NZ_CP089989:2983671-2984081 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T229870 NZ_CP124613:c895837-895538 [Vibrio sp. YMD68]
ATGCACCAGAGTAAATATAAACTAAGTAAATTAGCACAGACTCATTTACACAAAATCAAAAATTATACCGTTATAAACTT
TTCCGAGATGCAGTGGAACGCATACAAAGACACACTTATCACTGGGTTTCAGATGCTCGCTGACAATCCATCAGTAGGCA
GAAGCTGCAACGATTTATATGAAAATGGGGTTTATTTCCCGATTGGTAAGCACACGGCTTACTTTACCAAGGAAGACGGC
TTTATTTTGATCGTTGCAATCCTTGGACAATCGCAATTGCCACAGAATCATCTACGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT229870 WP_002916312.1 NZ_CP089989:2983424-2983690 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT229870 NZ_CP124613:c896087-895845 [Vibrio sp. YMD68]
ATGTACACATTAACAGCAAATGATGCCAAACGTAATTTCGGTGAGCTGCTGCTAAACGCTCAACGTGAGCCAGTTAAAAT
TAGTAAAAACAACAAAGATGCCGTTGTTGTGATGTCGATTAGAGACTATGAAGAACTTGAAGCTATGAAAGCCGATTACA
TCAAACATTGCTTTGAGTCCGCAAAAGCAGACTTAGCTCAAGGCAATGTAGTTGACGGTGAAAACTTCCTAAACGCGTTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References