Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1624168..1624684 Replicon chromosome
Accession NZ_CP089989
Organism Klebsiella pneumoniae strain LZKP00003

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LUR00_RS07735 Protein ID WP_009486548.1
Coordinates 1624168..1624452 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LUR00_RS07740 Protein ID WP_002886901.1
Coordinates 1624442..1624684 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUR00_RS07710 (LUR00_07710) 1619585..1619893 - 309 WP_016947038.1 PTS sugar transporter subunit IIB -
LUR00_RS07715 (LUR00_07715) 1619978..1620151 + 174 WP_002886906.1 hypothetical protein -
LUR00_RS07720 (LUR00_07720) 1620154..1620897 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LUR00_RS07725 (LUR00_07725) 1621254..1623392 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LUR00_RS07730 (LUR00_07730) 1623700..1624164 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LUR00_RS07735 (LUR00_07735) 1624168..1624452 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUR00_RS07740 (LUR00_07740) 1624442..1624684 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LUR00_RS07745 (LUR00_07745) 1624762..1626672 - 1911 WP_031593171.1 PRD domain-containing protein -
LUR00_RS07750 (LUR00_07750) 1626695..1627849 - 1155 WP_004178372.1 lactonase family protein -
LUR00_RS07755 (LUR00_07755) 1627916..1628656 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T229865 WP_009486548.1 NZ_CP089989:c1624452-1624168 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T229865 NZ_CP124600:c5622221-5621931 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT229865 WP_002886901.1 NZ_CP089989:c1624684-1624442 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT229865 NZ_CP124600:c5622517-5622218 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References