Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4025406..4026025 Replicon chromosome
Accession NZ_CP089986
Organism Klebsiella pneumoniae strain LZKP00001

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LUA09_RS19480 Protein ID WP_002892050.1
Coordinates 4025807..4026025 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LUA09_RS19475 Protein ID WP_002892066.1
Coordinates 4025406..4025780 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUA09_RS19465 (LUA09_19465) 4020558..4021751 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LUA09_RS19470 (LUA09_19470) 4021774..4024920 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LUA09_RS19475 (LUA09_19475) 4025406..4025780 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LUA09_RS19480 (LUA09_19480) 4025807..4026025 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LUA09_RS19485 (LUA09_19485) 4026184..4026750 + 567 WP_002892030.1 maltose O-acetyltransferase -
LUA09_RS19490 (LUA09_19490) 4026722..4026862 - 141 WP_032409038.1 hypothetical protein -
LUA09_RS19495 (LUA09_19495) 4026883..4027353 + 471 WP_002892026.1 YlaC family protein -
LUA09_RS19500 (LUA09_19500) 4027328..4028779 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LUA09_RS19505 (LUA09_19505) 4028880..4029578 + 699 WP_004893822.1 GNAT family protein -
LUA09_RS19510 (LUA09_19510) 4029575..4029715 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LUA09_RS19515 (LUA09_19515) 4029715..4029978 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T229858 WP_002892050.1 NZ_CP089986:4025807-4026025 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T229858 NZ_CP124576:3115867-3116145 [Sphingobium sp. AP49]
ATGACCCTGCCGGTCGTCTGGGATGACGAGGCAGAAACGGCCCTCCTGACCATCCTCGACTATATCGGCCCGCGCAACAA
ACTGGCAGCCGATCGCCTTTATGCCGCCATCCGGCACACTGCTGACAATCTGCCCAACCACCCTTATGCACATCGCCCCG
GCCGCACGCCCGGCACGCGCGAAGCCGTGGTTCACCCCAATTATATCCTCATCTACCGCGTCGCGATCGAGGCGATCGAG
ATATTGACGCTCGTCCACGCGCGCCAGCAATATCCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT229858 WP_002892066.1 NZ_CP089986:4025406-4025780 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT229858 NZ_CP124576:3115700-3115870 [Sphingobium sp. AP49]
ATGACCAAGCTCACCCCCATCGAGTCCGAGTTCGCGACGACCGAGGATGCGGAAGCCCATGACGCATGGGTCCGAGCCAA
GGTGGAACGTGCCCTCGCCTCCACCAAGCCGCGCATCCCGCATGACGCAGTCATGGCCAAGGCGCAGGCCGTTCTCGACA
AATATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References