Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4025406..4026025 Replicon chromosome
Accession NZ_CP089986
Organism Klebsiella pneumoniae strain LZKP00001

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LUA09_RS19480 Protein ID WP_002892050.1
Coordinates 4025807..4026025 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LUA09_RS19475 Protein ID WP_002892066.1
Coordinates 4025406..4025780 (+) Length 125 a.a.

Genomic Context


LUA09_RS19465LUA09_RS19470LUA09_RS19475LUA09_RS19480LUA09_RS19485LUA09_RS19495LUA09_RS19505LUA09_RS19490LUA09_RS19500LUA09_RS19510LUA09_RS19515
Location: 4020558..4021751 (1194 bp)
Type: Others
Protein ID: WP_004177236.1
Location: 4021774..4024920 (3147 bp)
Type: Others
Protein ID: WP_002892069.1
Location: 4025406..4025780 (375 bp)
Type: Antitoxin
Protein ID: WP_002892066.1
Location: 4025807..4026025 (219 bp)
Type: Toxin
Protein ID: WP_002892050.1
Location: 4026184..4026750 (567 bp)
Type: Others
Protein ID: WP_002892030.1
Location: 4026883..4027353 (471 bp)
Type: Others
Protein ID: WP_002892026.1
Location: 4028880..4029578 (699 bp)
Type: Others
Protein ID: WP_004893822.1
Location: 4026722..4026862 (141 bp)
Type: Others
Protein ID: WP_032409038.1
Location: 4027328..4028779 (1452 bp)
Type: Others
Protein ID: WP_002892023.1
Location: 4029575..4029715 (141 bp)
Type: Others
Protein ID: WP_002892018.1
Location: 4029715..4029978 (264 bp)
Type: Others
Protein ID: WP_002892011.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LUA09_RS19465 (LUA09_19465)4020558..4021751+1194WP_004177236.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
LUA09_RS19470 (LUA09_19470)4021774..4024920+3147WP_002892069.1multidrug efflux RND transporter permease subunit AcrB-
LUA09_RS19475 (LUA09_19475)4025406..4025780+375WP_002892066.1Hha toxicity modulator TomBAntitoxin
LUA09_RS19480 (LUA09_19480)4025807..4026025+219WP_002892050.1HHA domain-containing proteinToxin
LUA09_RS19485 (LUA09_19485)4026184..4026750+567WP_002892030.1maltose O-acetyltransferase-
LUA09_RS19490 (LUA09_19490)4026722..4026862-141WP_032409038.1hypothetical protein-
LUA09_RS19495 (LUA09_19495)4026883..4027353+471WP_002892026.1YlaC family protein-
LUA09_RS19500 (LUA09_19500)4027328..4028779-1452WP_002892023.1PLP-dependent aminotransferase family protein-
LUA09_RS19505 (LUA09_19505)4028880..4029578+699WP_004893822.1GNAT family protein-
LUA09_RS19510 (LUA09_19510)4029575..4029715-141WP_002892018.1type B 50S ribosomal protein L36-
LUA09_RS19515 (LUA09_19515)4029715..4029978-264WP_002892011.1type B 50S ribosomal protein L31-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T229858 WP_002892050.1 NZ_CP089986:4025807-4026025 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T229858 NZ_CP124576:3115867-3116145 [Sphingobium sp. AP49]
ATGACCCTGCCGGTCGTCTGGGATGACGAGGCAGAAACGGCCCTCCTGACCATCCTCGACTATATCGGCCCGCGCAACAA
ACTGGCAGCCGATCGCCTTTATGCCGCCATCCGGCACACTGCTGACAATCTGCCCAACCACCCTTATGCACATCGCCCCG
GCCGCACGCCCGGCACGCGCGAAGCCGTGGTTCACCCCAATTATATCCTCATCTACCGCGTCGCGATCGAGGCGATCGAG
ATATTGACGCTCGTCCACGCGCGCCAGCAATATCCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT229858 WP_002892066.1 NZ_CP089986:4025406-4025780 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT229858 NZ_CP124576:3115700-3115870 [Sphingobium sp. AP49]
ATGACCAAGCTCACCCCCATCGAGTCCGAGTTCGCGACGACCGAGGATGCGGAAGCCCATGACGCATGGGTCCGAGCCAA
GGTGGAACGTGCCCTCGCCTCCACCAAGCCGCGCATCCCGCATGACGCAGTCATGGCCAAGGCGCAGGCCGTTCTCGACA
AATATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A2P8K6F2


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GJ93

References