Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4025406..4026025 | Replicon | chromosome |
Accession | NZ_CP089986 | ||
Organism | Klebsiella pneumoniae strain LZKP00001 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | LUA09_RS19480 | Protein ID | WP_002892050.1 |
Coordinates | 4025807..4026025 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | LUA09_RS19475 | Protein ID | WP_002892066.1 |
Coordinates | 4025406..4025780 (+) | Length | 125 a.a. |
Genomic Context
Location: 4020558..4021751 (1194 bp)
Type: Others
Protein ID: WP_004177236.1
Type: Others
Protein ID: WP_004177236.1
Location: 4021774..4024920 (3147 bp)
Type: Others
Protein ID: WP_002892069.1
Type: Others
Protein ID: WP_002892069.1
Location: 4025406..4025780 (375 bp)
Type: Antitoxin
Protein ID: WP_002892066.1
Type: Antitoxin
Protein ID: WP_002892066.1
Location: 4025807..4026025 (219 bp)
Type: Toxin
Protein ID: WP_002892050.1
Type: Toxin
Protein ID: WP_002892050.1
Location: 4026184..4026750 (567 bp)
Type: Others
Protein ID: WP_002892030.1
Type: Others
Protein ID: WP_002892030.1
Location: 4026883..4027353 (471 bp)
Type: Others
Protein ID: WP_002892026.1
Type: Others
Protein ID: WP_002892026.1
Location: 4028880..4029578 (699 bp)
Type: Others
Protein ID: WP_004893822.1
Type: Others
Protein ID: WP_004893822.1
Location: 4026722..4026862 (141 bp)
Type: Others
Protein ID: WP_032409038.1
Type: Others
Protein ID: WP_032409038.1
Location: 4027328..4028779 (1452 bp)
Type: Others
Protein ID: WP_002892023.1
Type: Others
Protein ID: WP_002892023.1
Location: 4029575..4029715 (141 bp)
Type: Others
Protein ID: WP_002892018.1
Type: Others
Protein ID: WP_002892018.1
Location: 4029715..4029978 (264 bp)
Type: Others
Protein ID: WP_002892011.1
Type: Others
Protein ID: WP_002892011.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LUA09_RS19465 (LUA09_19465) | 4020558..4021751 | + | 1194 | WP_004177236.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
LUA09_RS19470 (LUA09_19470) | 4021774..4024920 | + | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
LUA09_RS19475 (LUA09_19475) | 4025406..4025780 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
LUA09_RS19480 (LUA09_19480) | 4025807..4026025 | + | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
LUA09_RS19485 (LUA09_19485) | 4026184..4026750 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
LUA09_RS19490 (LUA09_19490) | 4026722..4026862 | - | 141 | WP_032409038.1 | hypothetical protein | - |
LUA09_RS19495 (LUA09_19495) | 4026883..4027353 | + | 471 | WP_002892026.1 | YlaC family protein | - |
LUA09_RS19500 (LUA09_19500) | 4027328..4028779 | - | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
LUA09_RS19505 (LUA09_19505) | 4028880..4029578 | + | 699 | WP_004893822.1 | GNAT family protein | - |
LUA09_RS19510 (LUA09_19510) | 4029575..4029715 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
LUA09_RS19515 (LUA09_19515) | 4029715..4029978 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T229858 WP_002892050.1 NZ_CP089986:4025807-4026025 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T229858 NZ_CP124576:3115867-3116145 [Sphingobium sp. AP49]
ATGACCCTGCCGGTCGTCTGGGATGACGAGGCAGAAACGGCCCTCCTGACCATCCTCGACTATATCGGCCCGCGCAACAA
ACTGGCAGCCGATCGCCTTTATGCCGCCATCCGGCACACTGCTGACAATCTGCCCAACCACCCTTATGCACATCGCCCCG
GCCGCACGCCCGGCACGCGCGAAGCCGTGGTTCACCCCAATTATATCCTCATCTACCGCGTCGCGATCGAGGCGATCGAG
ATATTGACGCTCGTCCACGCGCGCCAGCAATATCCCTGA
ATGACCCTGCCGGTCGTCTGGGATGACGAGGCAGAAACGGCCCTCCTGACCATCCTCGACTATATCGGCCCGCGCAACAA
ACTGGCAGCCGATCGCCTTTATGCCGCCATCCGGCACACTGCTGACAATCTGCCCAACCACCCTTATGCACATCGCCCCG
GCCGCACGCCCGGCACGCGCGAAGCCGTGGTTCACCCCAATTATATCCTCATCTACCGCGTCGCGATCGAGGCGATCGAG
ATATTGACGCTCGTCCACGCGCGCCAGCAATATCCCTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT229858 WP_002892066.1 NZ_CP089986:4025406-4025780 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT229858 NZ_CP124576:3115700-3115870 [Sphingobium sp. AP49]
ATGACCAAGCTCACCCCCATCGAGTCCGAGTTCGCGACGACCGAGGATGCGGAAGCCCATGACGCATGGGTCCGAGCCAA
GGTGGAACGTGCCCTCGCCTCCACCAAGCCGCGCATCCCGCATGACGCAGTCATGGCCAAGGCGCAGGCCGTTCTCGACA
AATATAAATGA
ATGACCAAGCTCACCCCCATCGAGTCCGAGTTCGCGACGACCGAGGATGCGGAAGCCCATGACGCATGGGTCCGAGCCAA
GGTGGAACGTGCCCTCGCCTCCACCAAGCCGCGCATCCCGCATGACGCAGTCATGGCCAAGGCGCAGGCCGTTCTCGACA
AATATAAATGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |