Detailed information of TA system TA229856

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2614006..2615594
• Replicon: chromosome
• Accession: NZ_CP089986
• Organism: Klebsiella pneumoniae strain LZKP00001

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A9J6RYF8
• Locus tag: LUA09_RS12760
• Protein ID: WP_004892016.1
• Coordinates: 2614006..2615328 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LUA09_RS12765
• Protein ID: WP_004176198.1
• Coordinates: 2615328..2615594 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUA09_RS12745 (LUA09_12745)	2609063..2611563	+	2501	Protein_2495	fimbrial biogenesis outer membrane usher protein	-
LUA09_RS12750 (LUA09_12750)	2611551..2612555	+	1005	WP_004892012.1	fimbrial protein	-
LUA09_RS12755 (LUA09_12755)	2612697..2613989	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LUA09_RS12760 (LUA09_12760)	2614006..2615328	-	1323	WP_004892016.1	type II toxin-antitoxin system HipA family toxin	Toxin
LUA09_RS12765 (LUA09_12765)	2615328..2615594	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LUA09_RS12770 (LUA09_12770)	2615859..2616185	-	327	WP_004892019.1	hydroxyisourate hydrolase	-
LUA09_RS12775 (LUA09_12775)	2616182..2616682	-	501	WP_004892023.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LUA09_RS12780 (LUA09_12780)	2616660..2618039	-	1380	WP_004176204.1	nucleobase:cation symporter-2 family protein	-
LUA09_RS12785 (LUA09_12785)	2618385..2619539	+	1155	WP_004892025.1	FAD-dependent urate hydroxylase HpxO	-
LUA09_RS12790 (LUA09_12790)	2619520..2620443	-	924	WP_004892028.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	mgtC / iroE	2410538..2651077	240539

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49141.44 Da
• Isoelectric Point: 7.5357

>T229856 WP_004892016.1 NZ_CP089986:c2615328-2614006 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T229856 NZ_CP124576:c2898889-2898584 [Sphingobium sp. AP49]
ATGAAACTCGCTTGGTCAAATCGGGCGACGACTGATCGTCTGGCGATATTCATTTGGATTGCCGAGGATAATCCGCAAGC
CGCCGCCGATGTGGACGATCGGATCGAGGCAGCAGCCCAGCGCCTCAAAGATTTCCCGAATAGCGGGCGTCCGGGCCGGA
TCGAAGGCACGCGCGAATTGGTGATCGCGCACACGCCCTATATCGCACCTTACCAGATCATTGGGGATACCGTGCGCGTC
CTTCGCGTAATCCATGGCGCGCGCATGTGGCCCCACGACGTTCCCCCGGAATTCGAGCCGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT229856 WP_004176198.1 NZ_CP089986:c2615594-2615328 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT229856 NZ_CP124576:c2899191-2898886 [Sphingobium sp. AP49]
ATGGCCAATAATGCCCTGATTCAGACACGCATCGATTCGGACGTAAAGGACCGCGCCTCCGCCGTGTTCGAGCGGATGGG
GCTTACGGTATCAGACGCCGTGCGCATCCTTCTGACCCGCACCGCGCGCGAGGGCGTTGCCCCCATGGAGTTGCTGGTAG
AGCGGCAAGCTTATGACCAGTGGTTCCGGGCGCGGGTGCAGGAGGCGCTGGACGACGATCGGCCTGACATTAACGACGCC
GAGGTTTCCGCGCGGTTTGCTGAGCTTCGCGCGAATGCTCGAAAGGGCATCAAGCCGGTGCAATGA