Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4865114..4865754 Replicon chromosome
Accession NZ_CP089985
Organism Pseudomonas sp. HN11

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag LVW35_RS22140 Protein ID WP_233892039.1
Coordinates 4865114..4865527 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag LVW35_RS22145 Protein ID WP_233892040.1
Coordinates 4865524..4865754 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVW35_RS22130 (LVW35_22130) 4862343..4864298 - 1956 WP_033902234.1 acetate--CoA ligase -
LVW35_RS22135 (LVW35_22135) 4864697..4864966 + 270 WP_233892038.1 DUF2790 domain-containing protein -
LVW35_RS22140 (LVW35_22140) 4865114..4865527 - 414 WP_233892039.1 type II toxin-antitoxin system VapC family toxin Toxin
LVW35_RS22145 (LVW35_22145) 4865524..4865754 - 231 WP_233892040.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVW35_RS22150 (LVW35_22150) 4866239..4867489 + 1251 WP_233892041.1 ribonucleotide-diphosphate reductase subunit beta -
LVW35_RS22155 (LVW35_22155) 4867579..4867725 + 147 Protein_4368 HNH endonuclease -
LVW35_RS22160 (LVW35_22160) 4867798..4868442 + 645 WP_122728393.1 HAD-IB family hydrolase -
LVW35_RS22165 (LVW35_22165) 4868469..4868873 - 405 WP_043205781.1 type II toxin-antitoxin system VapC family toxin -
LVW35_RS22170 (LVW35_22170) 4868866..4869105 - 240 WP_080589294.1 type II toxin-antitoxin system VapB family antitoxin -
LVW35_RS22175 (LVW35_22175) 4869479..4870438 - 960 WP_233896534.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15216.66 Da        Isoelectric Point: 7.1885

>T229842 WP_233892039.1 NZ_CP089985:c4865527-4865114 [Pseudomonas sp. HN11]
MTTYMLDTCICSFIMRERPECVLNRLSAEVARNNRIVISAITYSEMRYGQIGKKASPKHKVLVDDFVKRLDEVLPWGLAA
VDATVNVKLSLTEMGLVIGQNDTAIAGHAIAAGCILVTNNVREFSRVTGLSYEDWVH

Download         Length: 414 bp

>T229842 NZ_CP124543:c4389318-4389019 [Halotia branconii CENA392]
ATGTCATTATTTCGCCTTACTGAATTAGCCAAGCAGGACTTACTATCAATCGGTCGTTACACTCAAAAAACGTGGGGAAT
TGAGCAAAGAAACCGTTATCTTACTATGTTGGACGACTGCTTTCAAATCTTGGCACGAAATCCACACAAAGGACGTGCTT
GTGATGAGATTAGCCCAGGATATCGGAAATACCATATTGGACGACATTTGATATTTTATCGGGAAACCGACGAATATATT
GATATCGTTCGCATTTTGCACGACCGCATGGATATAGAGTCTCATTTCAATAAAGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8723.76 Da        Isoelectric Point: 4.4230

>AT229842 WP_233892040.1 NZ_CP089985:c4865754-4865524 [Pseudomonas sp. HN11]
MRTVSIFKNGRNQAIRLPNDMAYEGVGELEITRNGDTITLRPVRPSWTSFAELPKADEDFLQERPDVIGDEDRFNL

Download         Length: 231 bp

>AT229842 NZ_CP124543:c4389555-4389322 [Halotia branconii CENA392]
ATGCAAAAAAATACAAGTGTTACCTTGGGGGAGCATTTTGAAGCGTTTATCGCCAGTCAGATCGAAAGCGGACGTTTCAA
CAGTGCCAGTGAGGCAATTCGGGCTGGACTGCGCTTGTTAGAAGAGCGAGAAATAAAGCTTGCCGCTTTGCAACGCGCTT
TAACAGAAGGGGAAAACAGCGGATTTACTGACTATTCTCTCTCAGGATTGCTTGCAGAACTTGACCGTGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References