Detailed information of TA system TA229840

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2433264..2433832
• Replicon: chromosome
• Accession: NZ_CP089985
• Organism: Pseudomonas sp. HN11

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LVW35_RS11295
• Protein ID: WP_233895535.1
• Coordinates: 2433626..2433832 (-)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LVW35_RS11290
• Protein ID: WP_233895534.1
• Coordinates: 2433264..2433629 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVW35_RS11275 (LVW35_11275)	2428779..2430419	-	1641	WP_233895530.1	methyl-accepting chemotaxis protein	-
LVW35_RS11280 (LVW35_11280)	2430696..2432051	+	1356	WP_233895532.1	MATE family efflux transporter	-
LVW35_RS11285 (LVW35_11285)	2432092..2433297	+	1206	WP_233895533.1	MFS transporter	-
LVW35_RS11290 (LVW35_11290)	2433264..2433629	-	366	WP_233895534.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LVW35_RS11295 (LVW35_11295)	2433626..2433832	-	207	WP_233895535.1	type II toxin-antitoxin system HicA family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7823.03 Da
• Isoelectric Point: 7.4686

>T229840 WP_233895535.1 NZ_CP089985:c2433832-2433626 [Pseudomonas sp. HN11]
MAFTWPELVTLLRRLGYTEIEGAGSRVKFDIGDPSTMITLHKPHPGHELKHYIRHQITEQLKSGELIQ

Nucleotide

• Length: 207 bp

>T229840 NZ_CP124543:3948068-3948334 [Halotia branconii CENA392]
ATGACTAGAAAGTTAGCATGGACAGATGAAGCTTGGAATGATTATCTATATTGGCAAGGGCAAGACAAGAAAATATTAAA
ACGAATTAACAAGCTAATTGAGGCAACAATCCAATTACCGTTTGAGGGAATTGGAAAACCAGAACTACTGAGGGAGAATT
TGGCTGGTTTTTGGTCGCGGCGAATCGATGATACGAACCGCTTAGTATATGCAGTAAATGACGAATATCTAACAATTATT
TCTTGTCGATACCATTATTTTGATTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13241.09 Da
• Isoelectric Point: 6.8278

>AT229840 WP_233895534.1 NZ_CP089985:c2433629-2433264 [Pseudomonas sp. HN11]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFREAVDDYLATCQTLGHHPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHGDDACPAVI

Nucleotide

• Length: 366 bp

>AT229840 NZ_CP124543:3947821-3948075 [Halotia branconii CENA392]
ATGAAAGTGGTGACTTTTAGCGAAGCGAGAAGTAATCTCAAGACTGTTTTAGACCAAGTGGTGGAAGATGTCGACTACAC
CATCATTACTAGAAGAGATGCGGAGGATGCTGTAGTGATGTCGCTAGAGTTATTTAATAGTTTGCTAGAGACTGTCCATT
TACTCAAGTCTCCTGCCAATGCTGCTCATTTAGAGCGTTCTATTGCTCAGTTCAAGCAGGGGAAAGTGGTAGGGCAAAAT
TTGTTGAATGACTAG