229838

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1512855..1513459 Replicon chromosome
Accession NZ_CP089985
Organism Pseudomonas sp. HN11

Toxin (Protein)


Gene name PumA Uniprot ID A0A432ACQ6
Locus tag LVW35_RS06910 Protein ID WP_068937614.1
Coordinates 1513166..1513459 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A223VPN1
Locus tag LVW35_RS06905 Protein ID WP_016975142.1
Coordinates 1512855..1513163 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVW35_RS06875 (LVW35_06875) 1508082..1508507 - 426 WP_233894411.1 low affinity iron permease family protein -
LVW35_RS06880 (LVW35_06880) 1508590..1509090 - 501 WP_233894412.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
LVW35_RS06885 (LVW35_06885) 1509170..1509490 - 321 WP_233894413.1 hypothetical protein -
LVW35_RS06890 (LVW35_06890) 1509523..1510440 - 918 WP_233894414.1 LysR family transcriptional regulator -
LVW35_RS06895 (LVW35_06895) 1510536..1511699 + 1164 WP_233894416.1 MFS transporter -
LVW35_RS06900 (LVW35_06900) 1511696..1512862 + 1167 WP_233894417.1 MFS transporter -
LVW35_RS06905 (LVW35_06905) 1512855..1513163 - 309 WP_016975142.1 putative addiction module antidote protein Antitoxin
LVW35_RS06910 (LVW35_06910) 1513166..1513459 - 294 WP_068937614.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVW35_RS06915 (LVW35_06915) 1513928..1514167 + 240 WP_095015065.1 DUF6124 family protein -
LVW35_RS06925 (LVW35_06925) 1514579..1515463 - 885 WP_233894418.1 alpha/beta hydrolase -
LVW35_RS06930 (LVW35_06930) 1515769..1516461 - 693 WP_233894419.1 pseudouridine synthase -
LVW35_RS06935 (LVW35_06935) 1516461..1516673 - 213 WP_233894420.1 cysteine-rich CWC family protein -
LVW35_RS06940 (LVW35_06940) 1516738..1518360 - 1623 WP_233894421.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(42-89)

Antitoxin

Uncharacterized protein HI1420

(3-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10895.68 Da        Isoelectric Point: 10.9446

>T229838 WP_068937614.1 NZ_CP089985:c1513459-1513166 [Pseudomonas sp. HN11]
VSYLIQQTQAFINWRSEVRDLRAKIAIGRRIERASMGNLGDIKTLGNGISEMRIDVGSGYRIYFTLRGKVIVILLVGGDK
SSQDTDIRRAKKLAKEV

Download         Length: 294 bp

>T229838 NZ_CP124543:c3350765-3350364 [Halotia branconii CENA392]
ATGACGAAAATAGATACTGTAATTGTCACAACTAGGTTAGATTTTATCGCTCGTTATCTTGACAATCTCAAAAGATTTGA
GCAAGTTAATTTAGATGATTATCTGGTTGACTTTGATACTCAACTAATTACTGAGAGGCTTTTACAATTAATGGCTCAAG
CAGCGATAGATATCAATGATCACATATTATCAAAGCTAAATCCAGGGAAGTCAGAAACTAACTTTGATTCTTTTATCAGC
CTTGGTAAATACGGTGTAATTACTCCTGCATTAGCCAGACAAATAGCACCATCATCAGGATTAAGAAATCGGCTTGTTCA
TGAATATGACGAAATAGATCCGCAGCAAGTTTTTAACTCTATCAGTTTTGCATTACGACTATATCCGCTTTATGTGCGCT
AA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11146.81 Da        Isoelectric Point: 5.6993

>AT229838 WP_016975142.1 NZ_CP089985:c1513163-1512855 [Pseudomonas sp. HN11]
MKQTLTTFDMAELLDSDEAISEYLSQVLADGDNQEFLRAIGYVAKARGMTKIAAEAGMGRESLYKAFAPGAKPRFETVLK
VLHSLGIDLFARAGHPVDRSII

Download         Length: 309 bp

>AT229838 NZ_CP124543:c3351208-3350771 [Halotia branconii CENA392]
ATGACAACACCAACAATTACAAAACTCAGAGAATTTGCTCAACAACTTCCTGAAAAAATACCTTATTTAAAAATGTTAGT
TTTATTTGGTTCTAGAGCTACTGGTGATATTCACGCTAAAAGTGACTGGGATTTTGCAGTTTTGTGTGATCAAGAACAAC
GTGAGGCTTATGTAAAAGATAACGCTTTTTTGTTGTTTGAGTTACCTATGGTGCTTGGGAAAGTATTCAAAATAAATTCT
GATCAAATCGACATTGTAGAGCTTAATCAATGTTCTGAACTAATATCACATTTTGTGGCTCGTGATGGCAAGGTTTTGTA
TGAGGATAATCCAGAAGAATTTGAAAAATTTAAACAAAAAATGCTATTGAGCAATTCAGAGCTTAAAAAAATCGAACATC
TTAAACGGCGAAATATTGAAAAGTTTCTCCAAAGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A432ACQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A223VPN1

References