Detailed information of TA system TA229834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 5045289..5045866
• Replicon: chromosome
• Accession: NZ_CP089979
• Organism: Fulvivirga sp. W9P-11

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LVD16_RS21190
• Protein ID: WP_233770292.1
• Coordinates: 5045289..5045531 (+)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LVD16_RS21195
• Protein ID: WP_233770293.1
• Coordinates: 5045528..5045866 (+)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVD16_RS21170 (LVD16_21170)	5041179..5041340	+	162	WP_202245868.1	DUF1328 domain-containing protein	-
LVD16_RS21175 (LVD16_21175)	5041544..5042914	-	1371	WP_233770289.1	cystathionine beta-synthase	-
LVD16_RS21180 (LVD16_21180)	5043043..5044362	+	1320	WP_233770290.1	carboxypeptidase-like regulatory domain-containing protein	-
LVD16_RS21185 (LVD16_21185)	5044346..5045101	-	756	WP_233770291.1	hypothetical protein	-
LVD16_RS21190 (LVD16_21190)	5045289..5045531	+	243	WP_233770292.1	type II toxin-antitoxin system HicA family toxin	Toxin
LVD16_RS21195 (LVD16_21195)	5045528..5045866	+	339	WP_233770293.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LVD16_RS21200 (LVD16_21200)	5045874..5048717	-	2844	WP_233770294.1	PD-(D/E)XK nuclease family protein	-
LVD16_RS21205 (LVD16_21205)	5048924..5050759	-	1836	WP_233770295.1	glycoside hydrolase family 15 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-80)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9263.91 Da
• Isoelectric Point: 10.5128

>T229834 WP_233770292.1 NZ_CP089979:5045289-5045531 [Fulvivirga sp. W9P-11]
MSKKQKLIDRFLGMPSDFHYDEMVQLLSYFGYSEVKKGKTSGSRVKFRNDAGINILLHKPHPSGIMKKYQMKQIKETLGI

Nucleotide

• Length: 243 bp

>T229834 NZ_CP124534:c4694795-4694661 [Xanthomonas campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12722.45 Da
• Isoelectric Point: 5.2470

>AT229834 WP_233770293.1 NZ_CP089979:5045528-5045866 [Fulvivirga sp. W9P-11]
MKYLKYKGYTGSIEYSPEDNLMYGKVLGIKGLISYEGQTGKQLEEDFKEAVDTYLEDCKEENSKPEKPFKGSFNVRIPSS
LHQQAALLAMETQTSLNSLVTEAIRFRISKEV

Nucleotide

• Length: 339 bp

>AT229834 NZ_CP124534:c4695024-4694872 [Xanthomonas campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA