Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1960122..1960747 Replicon chromosome
Accession NZ_CP089976
Organism Moraxella nasovis strain ZY201115

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LU293_RS09440 Protein ID WP_242747594.1
Coordinates 1960565..1960747 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LU293_RS09435 Protein ID WP_242747592.1
Coordinates 1960122..1960532 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU293_RS09400 (LU293_09400) 1955360..1955590 - 231 WP_242747579.1 exodeoxyribonuclease VII small subunit -
LU293_RS09405 (LU293_09405) 1955841..1957289 + 1449 WP_242747581.1 DASS family sodium-coupled anion symporter -
LU293_RS09410 (LU293_09410) 1957794..1958030 + 237 WP_242747584.1 hypothetical protein -
LU293_RS09415 (LU293_09415) 1958762..1959027 + 266 Protein_1831 HNH endonuclease -
LU293_RS09420 (LU293_09420) 1959159..1959356 + 198 WP_242747586.1 hypothetical protein -
LU293_RS09425 (LU293_09425) 1959356..1959547 + 192 WP_242747588.1 hypothetical protein -
LU293_RS09430 (LU293_09430) 1959544..1959894 + 351 WP_242747590.1 antiterminator Q family protein -
LU293_RS09435 (LU293_09435) 1960122..1960532 - 411 WP_242747592.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LU293_RS09440 (LU293_09440) 1960565..1960747 - 183 WP_242747594.1 type II toxin-antitoxin system HicA family toxin Toxin
LU293_RS09445 (LU293_09445) 1960857..1961321 + 465 WP_242747596.1 terminase small subunit -
LU293_RS09450 (LU293_09450) 1961318..1962502 + 1185 WP_242747598.1 terminase family protein -
LU293_RS09455 (LU293_09455) 1962796..1963830 + 1035 WP_242747600.1 phosphoribosyltransferase -
LU293_RS09460 (LU293_09460) 1963935..1964480 + 546 WP_242747602.1 hypothetical protein -
LU293_RS09465 (LU293_09465) 1964671..1965054 + 384 WP_242747604.1 phage tail terminator-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1959544..1982904 23360


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6809.94 Da        Isoelectric Point: 10.2989

>T229830 WP_242747594.1 NZ_CP089976:c1960747-1960565 [Moraxella nasovis]
VQSRVIIKMLIDDGWYEVNVVGSHHQYKHPTKKGKVTVKHPDKDIPIGTYKSILKQAGLN

Download         Length: 183 bp

>T229830 NZ_CP124533:c1234711-1234220 [Xanthomonas campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCTTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14793.77 Da        Isoelectric Point: 4.8781

>AT229830 WP_242747592.1 NZ_CP089976:c1960532-1960122 [Moraxella nasovis]
MYYPIAIESPANDNECFGVIVPDLPGCFSAGNSLDDAIKSVHEAISLHLDGLAKDGDDIPLAKNVADHAKNPDYQGMTWA
VVDIDLSAYMGKSEKINVTLPSRLIARIDEKVSAHKSLYKSRSNYLAQLASRDLMA

Download         Length: 411 bp

>AT229830 NZ_CP124533:c1234998-1234708 [Xanthomonas campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References