Detailed information of TA system TA229829

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 865561..866185
• Replicon: chromosome
• Accession: NZ_CP089976
• Organism: Moraxella nasovis strain ZY201115

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LU293_RS04275
• Protein ID: WP_242749211.1
• Coordinates: 865561..865722 (+)
• Length: 54 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LU293_RS04280
• Protein ID: WP_242747592.1
• Coordinates: 865775..866185 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LU293_RS04255 (LU293_04255)	861460..862101	-	642	WP_242749199.1	hypothetical protein	-
LU293_RS04260 (LU293_04260)	862094..863494	-	1401	WP_242749200.1	DUF4055 domain-containing protein	-
LU293_RS09810	863496..863624	-	129	WP_256462123.1	hypothetical protein	-
LU293_RS04265 (LU293_04265)	863740..864990	-	1251	WP_242749202.1	terminase family protein	-
LU293_RS04270 (LU293_04270)	864987..865451	-	465	WP_242747596.1	terminase small subunit	-
LU293_RS04275 (LU293_04275)	865561..865722	+	162	WP_242749211.1	type II toxin-antitoxin system HicA family toxin	Toxin
LU293_RS04280 (LU293_04280)	865775..866185	+	411	WP_242747592.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LU293_RS04285 (LU293_04285)	866518..866691	-	174	WP_242749213.1	hypothetical protein	-
LU293_RS04290 (LU293_04290)	866769..867119	-	351	WP_242749215.1	antiterminator Q family protein	-
LU293_RS04295 (LU293_04295)	867130..868032	-	903	WP_242749218.1	N-6 DNA methylase	-
LU293_RS04300 (LU293_04300)	868057..868830	-	774	WP_242749221.1	hypothetical protein	-
LU293_RS04305 (LU293_04305)	868827..869219	-	393	WP_242749223.1	DUF3310 domain-containing protein	-
LU293_RS04310 (LU293_04310)	869277..869609	-	333	WP_242749225.1	hypothetical protein	-
LU293_RS04315 (LU293_04315)	869606..869866	-	261	WP_242749227.1	hypothetical protein	-
LU293_RS04320 (LU293_04320)	869930..870133	-	204	WP_242749229.1	hypothetical protein	-
LU293_RS04325 (LU293_04325)	870123..870590	-	468	WP_242749231.1	recombination protein NinB	-
LU293_RS04330 (LU293_04330)	870583..870807	-	225	WP_242749233.1	hypothetical protein	-
LU293_RS04335 (LU293_04335)	870804..870968	-	165	WP_242749235.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	838502..882565	44063

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-53)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-130)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6085.08 Da
• Isoelectric Point: 10.1385

>T229829 WP_242749211.1 NZ_CP089976:865561-865722 [Moraxella nasovis]
VQSRVIIKMLIDDGWYEVNVVGSHHQYKHPTKKGKVTVKHPDKDIPIGTYKSI

Nucleotide

• Length: 162 bp

>T229829 NZ_CP124531:c4699371-4699219 [Xanthomonas campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14793.77 Da
• Isoelectric Point: 4.8781

>AT229829 WP_242747592.1 NZ_CP089976:865775-866185 [Moraxella nasovis]
MYYPIAIESPANDNECFGVIVPDLPGCFSAGNSLDDAIKSVHEAISLHLDGLAKDGDDIPLAKNVADHAKNPDYQGMTWA
VVDIDLSAYMGKSEKINVTLPSRLIARIDEKVSAHKSLYKSRSNYLAQLASRDLMA

Nucleotide

• Length: 411 bp

>AT229829 NZ_CP124531:c4699142-4699008 [Xanthomonas campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA