Detailed information of TA system TA229827

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 534246..534886
• Replicon: chromosome
• Accession: NZ_CP089975
• Organism: Moraxella sp. ZY190618

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LU290_RS02415
• Protein ID: WP_277808974.1
• Coordinates: 534246..534638 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LU290_RS02420
• Protein ID: WP_277808975.1
• Coordinates: 534635..534886 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LU290_RS02395 (LU290_02395)	531349..532071	-	723	WP_277808970.1	Bax inhibitor-1/YccA family protein	-
LU290_RS02400 (LU290_02400)	532295..533269	+	975	WP_277808971.1	NAD(+) kinase	-
LU290_RS02405 (LU290_02405)	533280..533570	+	291	WP_277808972.1	DUF1315 family protein	-
LU290_RS02410 (LU290_02410)	533714..534205	-	492	WP_277808973.1	amino acid racemase	-
LU290_RS02415 (LU290_02415)	534246..534638	-	393	WP_277808974.1	type II toxin-antitoxin system VapC family toxin	Toxin
LU290_RS02420 (LU290_02420)	534635..534886	-	252	WP_277808975.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LU290_RS02425 (LU290_02425)	535018..535767	+	750	WP_277808976.1	TSUP family transporter	-
LU290_RS02430 (LU290_02430)	535865..536743	+	879	WP_277808977.1	EamA family transporter	-
LU290_RS02435 (LU290_02435)	536821..538047	+	1227	WP_277808978.1	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	-
LU290_RS02440 (LU290_02440)	538037..538777	+	741	WP_277808979.1	SGNH/GDSL hydrolase family protein	-
LU290_RS02445 (LU290_02445)	538947..539348	-	402	WP_277808980.1	rhodanese-like domain-containing protein	-
LU290_RS02450 (LU290_02450)	539358..539696	-	339	WP_277808981.1	carboxymuconolactone decarboxylase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-49)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 15003.25 Da
• Isoelectric Point: 5.8722

>T229827 WP_277808974.1 NZ_CP089975:c534638-534246 [Moraxella sp. ZY190618]
MRYLLDTNIVIAFQKQNANLLNKMYRYPIDSFAISSIVHFELVFGACNSQQMEKNFKKIKELPFEILDFNQNDGFYAGQI
RSDLKAKGTPIGAYDTLIAGQTLANDLILITDNIKEFERVDGLKFENWLR

Nucleotide

• Length: 393 bp

>T229827 NZ_CP124531:c1235849-1235358 [Xanthomonas campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCTTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9658.93 Da
• Isoelectric Point: 4.8279

>AT229827 WP_277808975.1 NZ_CP089975:c534886-534635 [Moraxella sp. ZY190618]
MSQTATAKLFWTGNSQAVRLPKAFRFEGTEVKIKKQGRQVIIEPVVNNWDFVKDLEPFDESMERAIAELRNDPITERDWS
AFE

Nucleotide

• Length: 252 bp

>AT229827 NZ_CP124531:c1236136-1235846 [Xanthomonas campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA