Detailed information of TA system TA229826

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1767888..1768516
• Replicon: chromosome
• Accession: NZ_CP089974
• Organism: Moraxella sp. ZY171148

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LU276_RS08485
• Protein ID: WP_284673411.1
• Coordinates: 1768325..1768516 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LU276_RS08480
• Protein ID: WP_284673410.1
• Coordinates: 1767888..1768292 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LU276_RS08450 (LU276_08355)	1764732..1764995	+	264	WP_284673404.1	hypothetical protein	-
LU276_RS08455 (LU276_08360)	1765042..1765371	+	330	WP_284673405.1	phage tail protein	-
LU276_RS08460 (LU276_08365)	1765475..1765855	+	381	WP_284673406.1	hypothetical protein	-
LU276_RS08465 (LU276_08370)	1765861..1766538	+	678	WP_284673407.1	phage minor tail protein L	-
LU276_RS08470 (LU276_08375)	1766535..1766729	-	195	WP_284673408.1	hypothetical protein	-
LU276_RS08475 (LU276_08380)	1767126..1767920	+	795	WP_284673409.1	C40 family peptidase	-
LU276_RS08480 (LU276_08385)	1767888..1768292	-	405	WP_284673410.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LU276_RS08485 (LU276_08390)	1768325..1768516	-	192	WP_284673411.1	type II toxin-antitoxin system HicA family toxin	Toxin
LU276_RS08490 (LU276_08395)	1768596..1769162	+	567	WP_284673412.1	tail assembly protein	-
LU276_RS08495 (LU276_08400)	1769173..1773426	+	4254	WP_284673413.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1729616..1775291	45675

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7005.17 Da
• Isoelectric Point: 10.7158

>T229826 WP_284673411.1 NZ_CP089974:c1768516-1768325 [Moraxella sp. ZY171148]
MASSREVIKIIKADGWFQIKANAGSHKQFKHPTKKGRVTVPDPKKDLDKETVKSIMIQAGLSD

Nucleotide

• Length: 192 bp

>T229826 NZ_CP124530:c4653673-4653521 [Xanthomonas campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15264.41 Da
• Isoelectric Point: 6.0516

>AT229826 WP_284673410.1 NZ_CP089974:c1768292-1767888 [Moraxella sp. ZY171148]
MLYPIAVKLGNEQTAHAIFFPDIPHLVSACDELDDLLHCAIECIDLHFSGLAEDGEDIPLPTKFSTHQQNPKYTGYMWAW
VDIDLAKYNTKTHKINITLPQFLINQIDEKVASHKHLYKSRSNYLAQLASRDLA

Nucleotide

• Length: 405 bp

>AT229826 NZ_CP124530:c4653444-4653310 [Xanthomonas campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA