Detailed information of TA system TA229825

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1742303..1742948
• Replicon: chromosome
• Accession: NZ_CP089974
• Organism: Moraxella sp. ZY171148

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LU276_RS08310
• Protein ID: WP_284673376.1
• Coordinates: 1742760..1742948 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LU276_RS08305
• Protein ID: WP_284673375.1
• Coordinates: 1742303..1742710 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LU276_RS08265 (LU276_08175)	1737588..1737932	-	345	WP_284673367.1	hypothetical protein	-
LU276_RS08270 (LU276_08180)	1737945..1738319	-	375	WP_284673368.1	hypothetical protein	-
LU276_RS08275 (LU276_08185)	1738316..1738561	-	246	WP_284673369.1	hypothetical protein	-
LU276_RS08280 (LU276_08190)	1738575..1739270	-	696	WP_284673370.1	S24 family peptidase	-
LU276_RS08285 (LU276_08195)	1739400..1739627	+	228	WP_284673371.1	Cro/CI family transcriptional regulator	-
LU276_RS08290 (LU276_08200)	1739807..1741099	+	1293	WP_284673372.1	DUF1376 domain-containing protein	-
LU276_RS08295 (LU276_08205)	1741108..1741515	+	408	WP_284673373.1	VRR-NUC domain-containing protein	-
LU276_RS08300 (LU276_08210)	1741669..1742247	+	579	WP_284673374.1	hypothetical protein	-
LU276_RS08305 (LU276_08215)	1742303..1742710	-	408	WP_284673375.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LU276_RS08310 (LU276_08220)	1742760..1742948	-	189	WP_284673376.1	type II toxin-antitoxin system HicA family toxin	Toxin
LU276_RS08315 (LU276_08225)	1743124..1744089	+	966	WP_284673377.1	P63C domain-containing protein	-
LU276_RS08320 (LU276_08230)	1744405..1745175	+	771	WP_284673378.1	BRO family protein	-
LU276_RS08325 (LU276_08235)	1745601..1745963	+	363	WP_284673379.1	HNH endonuclease signature motif containing protein	-
LU276_RS08330 (LU276_08240)	1746047..1746532	+	486	WP_284673380.1	phage terminase small subunit P27 family	-
LU276_RS08335	1746660..1746788	+	129	WP_284673381.1	hypothetical protein	-
LU276_RS08340 (LU276_08245)	1747073..1747420	+	348	WP_284673382.1	phage antirepressor N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1729616..1775291	45675

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-130)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7003.11 Da
• Isoelectric Point: 10.3479

>T229825 WP_284673376.1 NZ_CP089974:c1742948-1742760 [Moraxella sp. ZY171148]
MPPSSDEMIKRITEDGWYFVKQKGSHKHFKHPTKEGKVTIPNGRESLPIGTLKSIIKQAGLE

Nucleotide

• Length: 189 bp

>T229825 NZ_CP124530:c4653444-4653310 [Xanthomonas campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14887.04 Da
• Isoelectric Point: 4.4574

>AT229825 WP_284673375.1 NZ_CP089974:c1742710-1742303 [Moraxella sp. ZY171148]
MLFPIAIEKPANEHECYGVIVPDIAGCFSTGNTPDEAIKNAYEAIALHLESMAEDGDTLPTAKPIFYHQDNADYQGMMWA
VVDMDMSTFMGKAEKINVTLPSLLISKIDEKVNAHKSLYKSRSNYLAQLAMADLA

Nucleotide

• Length: 408 bp

>AT229825 NZ_CP124530:c4653673-4653521 [Xanthomonas campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA