Detailed information of TA system TA229824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 483968..484542
• Replicon: chromosome
• Accession: NZ_CP089974
• Organism: Moraxella sp. ZY171148

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: LU276_RS02235
• Protein ID: WP_284674056.1
• Coordinates: 483968..484372 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: LU276_RS02240
• Protein ID: WP_046696179.1
• Coordinates: 484372..484542 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LU276_RS02220 (LU276_02210)	479193..480032	+	840	WP_284674053.1	sugar nucleotide-binding protein	-
LU276_RS02225 (LU276_02215)	480104..482467	-	2364	WP_284674054.1	PBP1A family penicillin-binding protein	-
LU276_RS02230 (LU276_02220)	482796..483962	-	1167	WP_284674055.1	2-methylaconitate cis-trans isomerase PrpF	-
LU276_RS02235 (LU276_02225)	483968..484372	-	405	WP_284674056.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
LU276_RS02240 (LU276_02230)	484372..484542	-	171	WP_046696179.1	hypothetical protein	Antitoxin
LU276_RS02245 (LU276_02235)	484590..486410	-	1821	WP_284674057.1	AAA family ATPase	-
LU276_RS02250 (LU276_02240)	486448..489027	-	2580	WP_284674058.1	Fe/S-dependent 2-methylisocitrate dehydratase AcnD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-126)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15006.13 Da
• Isoelectric Point: 4.2429

>T229824 WP_284674056.1 NZ_CP089974:c484372-483968 [Moraxella sp. ZY171148]
MEIICFPFERVIEINTYILSTEKGMKGQADIGKLQGALSRIDNAILYEGLNDVFEIASKYANSIAMAHALSDANKRTGLA
VALEYLSLNDYEITIDHILMADAMRDLVIGELTEIEFADILYHQYISSTNPQKE

Nucleotide

• Length: 405 bp

>T229824 NZ_CP124530:c1243943-1243452 [Xanthomonas campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCTTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6424.53 Da
• Isoelectric Point: 10.9086

>AT229824 WP_046696179.1 NZ_CP089974:c484542-484372 [Moraxella sp. ZY171148]
MNNKLSKYGINPTNRPKIPATKKLDLTGEQGQQIIKSETKLVLRTHKETFKRLADM

Nucleotide

• Length: 171 bp

>AT229824 NZ_CP124530:c1244230-1243940 [Xanthomonas campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA