Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1795..2705 Replicon plasmid pKP403-1
Accession NZ_CP089960
Organism Klebsiella pneumoniae strain KP403

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag LVQ74_RS25030 Protein ID WP_004026354.1
Coordinates 2235..2705 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag LVQ74_RS25025 Protein ID WP_004181895.1
Coordinates 1795..2238 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ74_RS25015 (LVQ74_24975) 1..423 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
LVQ74_RS25020 (LVQ74_24980) 423..1694 + 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
LVQ74_RS25025 (LVQ74_24985) 1795..2238 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
LVQ74_RS25030 (LVQ74_24990) 2235..2705 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
LVQ74_RS25035 (LVQ74_24995) 2815..3075 - 261 WP_004026352.1 hypothetical protein -
LVQ74_RS25040 (LVQ74_25000) 3798..3956 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
LVQ74_RS25045 (LVQ74_25005) 4559..5533 + 975 WP_014386572.1 hypothetical protein -
LVQ74_RS25050 (LVQ74_25010) 5731..6108 - 378 WP_004181901.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(B) / aph(3'')-Ib / aph(6)-Id - 1..298594 298594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T229815 WP_004026354.1 NZ_CP089960:2235-2705 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T229815 NZ_CP124522:c4078882-4078598 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT229815 WP_004181895.1 NZ_CP089960:1795-2238 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT229815 NZ_CP124522:c4079114-4078872 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References