229814

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5086807..5087432 Replicon chromosome
Accession NZ_CP089959
Organism Klebsiella pneumoniae strain KP403

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag LVQ74_RS24650 Protein ID WP_002882817.1
Coordinates 5086807..5087190 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LVQ74_RS24655 Protein ID WP_004150355.1
Coordinates 5087190..5087432 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ74_RS24635 (LVQ74_24595) 5084173..5085075 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LVQ74_RS24640 (LVQ74_24600) 5085072..5085707 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LVQ74_RS24645 (LVQ74_24605) 5085704..5086633 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LVQ74_RS24650 (LVQ74_24610) 5086807..5087190 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
LVQ74_RS24655 (LVQ74_24615) 5087190..5087432 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LVQ74_RS24660 (LVQ74_24620) 5087637..5088554 + 918 WP_004181612.1 alpha/beta hydrolase -
LVQ74_RS24665 (LVQ74_24625) 5088568..5089509 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LVQ74_RS24670 (LVQ74_24630) 5089554..5089991 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LVQ74_RS24675 (LVQ74_24635) 5089988..5090848 - 861 WP_004146232.1 virulence factor BrkB family protein -
LVQ74_RS24680 (LVQ74_24640) 5090842..5091441 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T229814 WP_002882817.1 NZ_CP089959:c5087190-5086807 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T229814 NZ_CP124522:c4037781-4037473 [Salmonella enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT229814 WP_004150355.1 NZ_CP089959:c5087432-5087190 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT229814 NZ_CP124522:c4038023-4037784 [Salmonella enterica]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References