Detailed information of TA system TA229813

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4749848..4751529
• Replicon: chromosome
• Accession: NZ_CP089959
• Organism: Klebsiella pneumoniae strain KP403

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A483J778
• Locus tag: LVQ74_RS23085
• Protein ID: WP_023159070.1
• Coordinates: 4749848..4750765 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LVQ74_RS23090
• Protein ID: WP_004177809.1
• Coordinates: 4750771..4751529 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVQ74_RS23065 (LVQ74_23025)	4745154..4746674	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LVQ74_RS23070 (LVQ74_23030)	4746671..4747669	+	999	WP_002885172.1	ribose ABC transporter permease	-
LVQ74_RS23075 (LVQ74_23035)	4747700..4748641	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LVQ74_RS23080 (LVQ74_23040)	4748716..4749723	+	1008	WP_004177805.1	carbohydrate kinase family protein	-
LVQ74_RS23085 (LVQ74_23045)	4749848..4750765	-	918	WP_023159070.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LVQ74_RS23090 (LVQ74_23050)	4750771..4751529	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LVQ74_RS23095 (LVQ74_23055)	4751615..4752343	-	729	WP_023159071.1	response regulator transcription factor	-
LVQ74_RS23100 (LVQ74_23060)	4752616..4754763	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LVQ74_RS23105 (LVQ74_23065)	4754993..4755679	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34786.29 Da
• Isoelectric Point: 5.7845

>T229813 WP_023159070.1 NZ_CP089959:c4750765-4749848 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARRTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T229813 NZ_CP124522:c3987797-3987510 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT229813 WP_004177809.1 NZ_CP089959:c4751529-4750771 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT229813 NZ_CP124522:c3987523-3987221 [Salmonella enterica]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Structures

Toxin

• AlphaFold DB: A0A483J778

Antitoxin

• AlphaFold DB: A6TH05