229812

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4573443..4573959 Replicon chromosome
Accession NZ_CP089959
Organism Klebsiella pneumoniae strain KP403

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LVQ74_RS22195 Protein ID WP_004178374.1
Coordinates 4573443..4573727 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LVQ74_RS22200 Protein ID WP_002886901.1
Coordinates 4573717..4573959 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ74_RS22170 (LVQ74_22130) 4568838..4569101 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LVQ74_RS22175 (LVQ74_22135) 4569231..4569404 + 174 WP_040200691.1 hypothetical protein -
LVQ74_RS22180 (LVQ74_22140) 4569407..4570150 + 744 WP_032430531.1 MurR/RpiR family transcriptional regulator -
LVQ74_RS22185 (LVQ74_22145) 4570507..4572645 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LVQ74_RS22190 (LVQ74_22150) 4572975..4573439 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LVQ74_RS22195 (LVQ74_22155) 4573443..4573727 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVQ74_RS22200 (LVQ74_22160) 4573717..4573959 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LVQ74_RS22205 (LVQ74_22165) 4574037..4575947 - 1911 WP_023159545.1 PRD domain-containing protein -
LVQ74_RS22210 (LVQ74_22170) 4575970..4577124 - 1155 WP_023159544.1 lactonase family protein -
LVQ74_RS22215 (LVQ74_22175) 4577191..4577931 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T229812 WP_004178374.1 NZ_CP089959:c4573727-4573443 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T229812 NZ_CP124522:3602455-3602712 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT229812 WP_002886901.1 NZ_CP089959:c4573959-4573717 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT229812 NZ_CP124522:c3602630-3602298 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References