229810

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3859513..3860132 Replicon chromosome
Accession NZ_CP089959
Organism Klebsiella pneumoniae strain KP403

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LVQ74_RS18810 Protein ID WP_002892050.1
Coordinates 3859914..3860132 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LVQ74_RS18805 Protein ID WP_002892066.1
Coordinates 3859513..3859887 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ74_RS18795 (LVQ74_18765) 3854665..3855858 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LVQ74_RS18800 (LVQ74_18770) 3855881..3859027 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LVQ74_RS18805 (LVQ74_18775) 3859513..3859887 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LVQ74_RS18810 (LVQ74_18780) 3859914..3860132 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LVQ74_RS18815 (LVQ74_18785) 3860291..3860857 + 567 WP_023158101.1 maltose O-acetyltransferase -
LVQ74_RS18820 (LVQ74_18790) 3860829..3860969 - 141 WP_004147370.1 hypothetical protein -
LVQ74_RS18825 (LVQ74_18795) 3860990..3861460 + 471 WP_002892026.1 YlaC family protein -
LVQ74_RS18830 (LVQ74_18800) 3861435..3862886 - 1452 WP_023158103.1 PLP-dependent aminotransferase family protein -
LVQ74_RS18835 (LVQ74_18805) 3862987..3863685 + 699 WP_002892021.1 GNAT family protein -
LVQ74_RS18840 (LVQ74_18810) 3863682..3863822 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LVQ74_RS18845 (LVQ74_18815) 3863822..3864085 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T229810 WP_002892050.1 NZ_CP089959:3859914-3860132 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T229810 NZ_CP124522:c2693588-2693485 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT229810 WP_002892066.1 NZ_CP089959:3859513-3859887 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT229810 NZ_CP124522:2693483-2693628 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References