Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 794223..794880 Replicon chromosome
Accession NZ_CP089959
Organism Klebsiella pneumoniae strain KP403

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LVQ74_RS03950 Protein ID WP_002916310.1
Coordinates 794470..794880 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LVQ74_RS03945 Protein ID WP_002916312.1
Coordinates 794223..794489 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ74_RS03920 (LVQ74_03920) 789431..790864 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LVQ74_RS03925 (LVQ74_03925) 790983..791711 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LVQ74_RS03930 (LVQ74_03930) 791761..792072 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LVQ74_RS03935 (LVQ74_03935) 792236..792895 + 660 WP_002916317.1 hemolysin III family protein -
LVQ74_RS03940 (LVQ74_03940) 792994..793977 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LVQ74_RS03945 (LVQ74_03945) 794223..794489 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LVQ74_RS03950 (LVQ74_03950) 794470..794880 + 411 WP_002916310.1 protein YgfX Toxin
LVQ74_RS03955 (LVQ74_03955) 794887..795408 - 522 WP_004144730.1 flavodoxin FldB -
LVQ74_RS03960 (LVQ74_03960) 795509..796405 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LVQ74_RS03965 (LVQ74_03965) 796428..797141 + 714 WP_071081169.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LVQ74_RS03970 (LVQ74_03970) 797147..798880 + 1734 WP_071081170.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T229799 WP_002916310.1 NZ_CP089959:794470-794880 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T229799 NZ_CP124517:4610452-4610754 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT229799 WP_002916312.1 NZ_CP089959:794223-794489 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT229799 NZ_CP124517:4610790-4611131 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References